5α-Dihydrodeoxycorticosterone
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5α-Dihydrodeoxycorticosterone
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CAS No:
298-36-2
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Formula:
C21H32O3
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Chemical Name:
5α-Dihydrodeoxycorticosterone
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Synonyms:
Pregnane-3,20-dione,21-hydroxy-,(5α)-;5α-Pregnane-3,20-dione,21-hydroxy-;(5α)-21-Hydroxypregnane-3,20-dione;Allopregnane-21-ol-3,20-dione;21-Hydroxy-5α-pregnane-3,20-dione;5α-Dihydrodeoxycorticosterone;5α-Dihydro-11-deoxycorticosterone;5α-Pregnan-21-ol-3,20-dione
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CAS No:
Description
5alpha-dihydrodeoxycorticosterone is a 3-oxo-5alpha-steroid formed from 11-deoxycorticosterone by reduction across the C4-C5 double bond. It has a role as a progesterone receptor agonist, a GABA modulator and an anticonvulsant. It is a 21-hydroxy steroid, a 3-oxo-5alpha-steroid, a 20-oxo steroid, a primary alpha-hydroxy ketone and a mineralocorticoid. It derives from an 11-deoxycorticosterone. It derives from a hydride of a 5alpha-pregnane.
Characteristics
54.37000
3.77580
1.11g/cm3
157-159 °C
468.6ºC at 760mmHg
251.3ºC
1.531
9.42E-11mmHg at 25°C
5α-Dihydrodeoxycorticosterone Use and Manufacturing
The product can be prepared by hydrolyzing 21-hydroxypregnant-4-ene-3, 20-dione-21-acetate to remove acetyl group, and then catalytically hydrogenating.
5α-Dihydrodeoxycorticosterone could promote prostate cancer cell proliferation through androgen receptor (AR) activation.
Computed Properties
Molecular Weight:332.5
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:332.23514488
Monoisotopic Mass:332.23514488
Topological Polar Surface Area:54.4
Heavy Atom Count:24
Complexity:555
Defined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes