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Benproperine

Benproperine structure

CAS No:
2156-27-6
Formula:
C21H27NO
Chemical Name:
Benproperine
Synonyms:
Piperidine,1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]-;Piperidine,1-[1-methyl-2-[(α-phenyl-o-tolyl)oxy]ethyl]-;1-[1-Methyl-2-[2-(phenylmethyl)phenoxy]ethyl]piperidine;1-[2-(2-Benzylphenoxy)-1-methylethyl]piperidine;Benproperine;138663-99-7
Categories:
Active Pharmaceutical Ingredients > Respiratory Drugs

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Description

1-[1-[2-(phenylmethyl)phenoxy]propan-2-yl]piperidine is a diarylmethane.

Benproperine Basic Attributes

Molecular Weight：

309.45

Exact Mass：

309.45

EC Number：

1308068-626-2

ATC Code：

R - Respiratory system

HScode：

2933399090

Characteristics

PSA：

12.5

XLogP3：

4.46850

Density：

1.04g/cm3

Boiling Point：

159-161 °C @ Press: 0.2 Torr

Flash Point：

126.8ºC

Refractive Index：

1.5614 (estimate)

Toxicity：

LD50 orally in mice: 1087 mg/kg (Tellini, De Fina)

Drug Information

MeSH Entry Terms：

benproperine

Benproperine Use and Manufacturing

Non-narcotic potent antitussive, mainly used for irritating dry cough and cough caused by various reasons.

Computed Properties

Molecular Weight:309.4
XLogP3:5.1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:309.209264485
Monoisotopic Mass:309.209264485
Topological Polar Surface Area:12.5
Heavy Atom Count:23
Complexity:320
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a non-narcotic antitussive drug that has the effect of reducing the impulse of lung stretch receptors and reducing the excitability of the cough center.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Benproperine phosphate oral solution
Ingredients	Benproperine
Indication	Not yet clear.
Specifications	120 ml: 120 mg
Manufacturer	Jiangxi Xinglin Baima Pharmaceutical Co., Ltd.

Benproperine phosphate oral solution
Ingredients	Each bottle of this product contains 0.08 grams of benproperine and 0.1 grams of auxiliary materials such as honey, sucrose, essence and sodium benzoate.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Based on C21H27NO 100ml:100mg
Manufacturer	Beijing Jiulong Pharmaceutical Co., Ltd.

Benproperine Phosphate Tablets
Ingredients	Each tablet of this product contains 26.4 mg of the main ingredient, benproperine phosphate (equivalent to 20 mg of benproperine).
Specifications	20mg (in terms of C21H27NO)

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