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1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)-

1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)- structure

CAS No:
2188-68-3
Formula:
C16H17NO4.ClH
Chemical Name:
1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)-
Synonyms:
1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-,hydrochloride (1:1),(1S,2S,12bS,12cS)-;Lycoran-1α,2β-diol,3,3a-didehydro-,hydrochloride;1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-,hydrochloride,(1S,2S,12bS,12cS)-;Galanthan-1,2-diol,3,12-didehydro-9,10-[methylenebis(oxy)]-,hydrochloride,(1α,2β)-;Lycorine hydrochloride;Licorin hydrochloride
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

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Description

Lycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.IC50: 1.2μM (Hey1B cell)[2]In vitro:Lycorine (hydrochloride) executed an anti-melanoma vasculogenic effect by inhibiting VE-cadherin gene expression in C8161 cells and caused a decrease in cell surface exposure of VE-cadherin protein. Consistently, LH significantly suppressed VE-cadherin gene promoter activity. [1]Lycorine (hydrochloride) effectively inhibited mitotic proliferation of Hey1B cells (half

1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)- Basic Attributes

Molecular Weight：

287.31

Exact Mass：

323.092

EC Number：

207-503-6

UNII：

58F70VH0HS

Characteristics

PSA：

62.2

XLogP3：

0.68650

Appearance：

fine crystal powder.

Melting Point：

206 °C

Boiling Point：

477.4°C at 760 mmHg

Flash Point：

242.5ºC

Storage Conditions：

2-8°C

Vapor Pressure：

6.37E-10mmHg at 25°C

Safety Information

Packing level：

Ⅲ

Transport codes：

UN28116.1/PG3

wgk germany：

hazard class code：

safety instructions：

Marks：

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)- Use and Manufacturing

A selective inhibitor of peptidyl transferase center (PTC).

Computed Properties

Molecular Weight:323.77
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Exact Mass:323.0924357
Monoisotopic Mass:323.0924357
Topological Polar Surface Area:62.2
Heavy Atom Count:22
Complexity:481
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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High purity Lycorinehydrochloride powder 2188-68-3

Unit Price: $25.87-32.34 /UNIT FOB

CAS No.: 2188-68-3

Grade: Chemical Grade

Content: 99%

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Lycorinehydrochloride

CAS No.: 2188-68-3

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Guide of 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)-

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
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1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)-

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