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Home > Encyclopedia > Tosyl-L-lysine chloromethyl ketone

Tosyl-L-lysine chloromethyl ketone

Tosyl-L-lysine chloromethyl ketone structure

Tosyl-L-lysine chloromethyl ketone 

structure
  • CAS No:

    2364-87-6

  • Formula:

    C14H21ClN2O3S

  • Chemical Name:

    Tosyl-L-lysine chloromethyl ketone

  • Synonyms:

    Benzenesulfonamide,N-[(1S)-5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-;p-Toluenesulfonamide,N-[5-amino-1-(chloroacetyl)pentyl]-,L-;Benzenesulfonamide,N-[5-amino-1-(chloroacetyl)pentyl]-4-methyl-,(S)-;Benzenesulfonamide,N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methyl-;N-[(1S)-5-Amino-1-(2-chloroacetyl)pentyl]-4-methylbenzenesulfonamide;1-Chloro-3-tosylamido-7-amino-L-2-heptanone;TLCK;Nα-Tosyl-L-lysine chloromethyl ketone;Nα-p-Tosyl-L-lysine chloromethyl ketone;Tosyllysine chloromethyl ketone;L-1-Chloro-3-tosylamido-7-amino-2-heptanone;Tosyllysyl chloromethyl ketone;α-N-(p-Tosyl)-L-lysyl chloromethyl ketone;N-Tosyl-L-lysyl chloromethyl ketone;Nα-p-Tosyl-L-lysylchloromethyl ketone;N-Tosyl-L-lysine chloromethyl ketone;Nα-Tosyl-L-lysyl chloromethyl ketone;Tosyl-L-lysine chloromethyl ketone;130021-39-5;3414-37-7

Description

Tos-Lys-CH2Cl is a sulfonic acid derivative.|An inhibitor of SERINE ENDOPEPTIDASES. Acts as an alkylating agent and is known to interfere with the translation process.

Tosyl-L-lysine chloromethyl ketone Basic Attributes

369.30700

332.85

DTXSID7048459

Characteristics

97.64000

4.55280

1.242g/cm3

-165ºC (dec.)

509.8ºC at 760mmHg

262.1ºC

Safety Information

3

R36/37/38

26-36

XT5160000

Xi: Irritant;

Drug Information

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. (See all compounds classified as Alkylating Agents.)|Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)|Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES. (See all compounds classified as Serine Proteinase Inhibitors.)

Chloromethane, Tosyllysyl

Computed Properties

Molecular Weight:332.8
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:332.0961414
Monoisotopic Mass:332.0961414
Topological Polar Surface Area:97.6
Heavy Atom Count:21
Complexity:414
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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