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Terpin hydrate

Terpin hydrate structure

CAS No:
2451-01-6
Formula:
C10H20O2.H2O
Chemical Name:
Terpin hydrate
Synonyms:
Cyclohexanemethanol,4-hydroxy-α,α,4-trimethyl-,hydrate (1:1),cis-;p-Menthane-1,8-diol,monohydrate;Cyclohexanemethanol,4-hydroxy-α,α,4-trimethyl-,monohydrate,cis-;Terpin hydrate;Terpin monohydrate;Terpinol hydrate;cis-p-Menthane-1,8-diol monohydrate;cis-Terpin hydrate;Terpinene hydrate;16485-15-7
Categories:
Analytical Chemistry > Standard

Description

Terpin hydrate is an expectorant, commonly used to loosen mucus in patients presenting with acute or chronic bronchitis, and related conditions.

Terpin hydrate is an expectorant, commonly used to loosen mucus and ease congestion in patients presenting with acute or chronic bronchitis, and related pulmonary conditions. It is derived from sources such as turpentine, oregano, thyme and eucalyptus. It was popular in the United States since the late nineteenth century, but was removed from marketed medications in the 1990s after FDA stated that "based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients". Elixirs of terpin hydrate are still available to patients as prescription medications to be prepared by specialty compounding pharmacies.

Terpin hydrate Basic Attributes

Molecular Weight：

190.28

Exact Mass：

190.156891

EC Number：

209-279-5

UNII：

S3V868548T

HScode：

2915900090

Characteristics

PSA：

41.5

XLogP3：

2.32

Appearance：

colorless ,lustrous crystal or white powder

Melting Point：

116 °C

Boiling Point：

bp 258°

Flash Point：

119ºC

Refractive Index：

1.491

Water Solubility：

Partially soluble in cold water

Vapor Pressure：

0.001mmHg at 25°C

Safety Information

Transport codes：

UN 3265 8 / PGII

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36/37/39

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity Summary：

Overdose can cause nausea, vomiting and abdominal pain.

Drug Information

Drug Indication：

Terpin hydrate is used in the treatment of acute and chronic bronchitis, pneumonia, bronchiectasis, chronic obstructive pulmonary disease, infectious and inflammatory diseases of the upper respiratory tract.

Pharmacology：

It acts to facilitate the removal of mucus from the respiratory tract. It prevents the exacerbation of excessive mucus production and secretion due to airway bacterial or viral infections, asthma or chronic bronchitis. Expectorants like terpin hydrate change mucus consistency and make coughing more productive.

MeSH：

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)

Mechanism of Action：

Terpin hydrate improves mucociliary function by working directly on the bronchial secretory cells in the lower respiratory tract to liquify and facilitate the elimination of bronchial secretionsas well as exerting a weak antiseptic effect on the pulmonary parenchyma. It is thought to increase the amount of fluid in the respiratory tract, which increases the flow and clearance of local irritants and as well as reducing the viscosity of mucus.

MeSH Entry Terms：

2-(2'-hydroxypropan-2'-yl)-5-methylcyclohexanol

Terpin hydrate Use and Manufacturing

expectorant

Computed Properties

Molecular Weight:190.28
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:190.15689456
Monoisotopic Mass:190.15689456
Topological Polar Surface Area:41.5
Heavy Atom Count:13
Complexity:155
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Terpin hydrate

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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TERPIN MONOHYDRATE

CAS No.: 2451-01-6

Content: 99.00%

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