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Troleandomycin

Troleandomycin structure

CAS No:
2751-09-9
Formula:
C41H67NO15
Chemical Name:
Troleandomycin
Synonyms:
Oleandomycin,2′′,4′,11-triacetate;Oleandomycin triacetate;Oleandomycin,triacetate (ester);Oxiraneheptanoic acid,2-(3,5-dihydroxy-2,4-dimethylhexanoyl)-δ-[[4-(dimethylamino)tetrahydro-3-hydroxy-6-methylpyran-2-yl]oxy]-α,γ,ε-trimethyl-β-[(tetrahydro-5-hydroxy-4-methoxy-6-methylpyran-2-yl)oxy]-,μ-lactone,triacetate;1,9-Dioxaspiro[2.13]hexadecane,oleandomycin deriv.;Wy 651;Cyclamycin;Evramicina;Oleandomycin triacetyl ester;TAO;Triacetyloleandomycin;Troleandomycin;TAO (pharmaceutical);Triocetin;Wytrion;Evramycin;NSC 108166;Oleomycin;Acetyloleandomycin;423764-89-0;1236362-37-0
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

ChEBI: A semi-synthetic macrolide antibiotic obtained by acetylation of the three free hydroxy groups of oleandomycin. Troleandomycin is only found in individuals that have taken the drug.

A macrolide antibiotic that is similar to ERYTHROMYCIN.

Troleandomycin Basic Attributes

Molecular Weight：

813.97

Exact Mass：

813.97

EC Number：

220-392-9

DSSTox ID：

DTXSID2023721

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

184.19000

XLogP3：

3.62090

Appearance：

Solid

Density：

1.19g/cm3

Melting Point：

170 °C

Boiling Point：

812.5ºC at 760mmHg

Flash Point：

445.2ºC

Refractive Index：

1.515

Water Solubility：

0.25g/L(28 ºC)

Storage Conditions：

0-6°C

Toxicity：

LD50 oral in mouse: > 5gm/kg

Specific rotation：

D25 -23° (methanol)

Safety Information

wgk germany：

hazard class code：

36/37/38

safety instructions：

22-24/25-36-26

RTECS Number：

RJ9900000

Marks：

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, and P362|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

Oleandocetin

Troleandomycin Use and Manufacturing

Uses

Antibacterial.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:814.0
XLogP3:4.3
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:12
Exact Mass:813.45107043
Monoisotopic Mass:813.45107043
Topological Polar Surface Area:184
Heavy Atom Count:57
Complexity:1430
Defined Atom Stereocenter Count:18
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes