5-Chloro-2′-deoxyuridine
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5-Chloro-2′-deoxyuridine
structure -
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CAS No:
50-90-8
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Formula:
C9H11ClN2O5
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Chemical Name:
5-Chloro-2′-deoxyuridine
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Synonyms:
Uridine,5-chloro-2′-deoxy-;5-Chloro-2′-deoxyuridine;5-Chlorodeoxyuridine;2′-Deoxy-5-chlorouridine;Chlorodeoxyuridine;1236363-50-0
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CAS No:
Description
5-Chloro-2'-deoxyuridine, a thymine analog, is to study the potential of hypochlorous acid damage to DNA and DNA precursors.
Characteristics
104.55000
1.67 g/cm3
174-178 °C (decomp)
1.644
−20°C
Celiac-rat LD50: 2000 mg/kg
Flammable; Fire site releases toxic nitrogen oxides, chloride fumes
Safety Information
NONH for all modes of transport
3
20/21/22-40
36/37/39-45
YU7400000
Xn
The warehouse is low-temperature, ventilated and dry
P280
H302-H312-H332-H351
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
5-Chloro-2′-deoxyuridine Use and Manufacturing
5-Chloro-2'-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.[Cayman Chemical]
Computed Properties
Molecular Weight:262.65
XLogP3:-0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:262.0356491
Monoisotopic Mass:262.0356491
Topological Polar Surface Area:99.1
Heavy Atom Count:17
Complexity:386
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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