2-Amino-5-nitropyrimidine
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2-Amino-5-nitropyrimidine
structure -
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CAS No:
3073-77-6
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Formula:
C4H4N4O2
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Chemical Name:
2-Amino-5-nitropyrimidine
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Synonyms:
2-Pyrimidinamine,5-nitro-;Pyrimidine,2-amino-5-nitro-;5-Nitro-2-pyrimidinamine;2-Amino-5-nitropyrimidine;Enheptin P;5-Nitro-2-aminopyrimidine;NSC 37682;NSC 48065;5-Nitropyrimidin-2-ylamine;5-Nitropyrimidine-2-amine
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CAS No:
2-Amino-5-nitropyrimidine Basic Attributes
140.1
140.10
221-348-1
48065|37682
DTXSID00184753
29335990
Characteristics
97.6
-0.3
Light yellow Fine Crystalline Powder
1.6±0.1 g/cm3
236 °C
402.4°C at 760 mmHg
197.1±26.5 °C
1.660
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Safety Information
IRRITANT
NONH for all modes of transport
3
36/37/38-20/21/22
26-37/39-36
Xi,Xn
Irritant
Stable under normal temperatures and pressures.
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Amino-5-nitropyrimidine Use and Manufacturing
To a three-neck flask were added Toa three-neck flask were added 5-Nitropyrimidin-2-amine (1 eq), Boc2O (1.2 eq), 4-dimethylaminopyridine(0.2eq) were added to a flask under nitrogen atmosphere and dichloromethaneat room temperature. The mixture was stirred at room temperature overnight.Ethyl acetate was added and a precipitated formed was filtered and washedwith ethyl acetate to obtain the desired tert-butyl (5-nitropyridin-2-yl)carbamate.(Crude contains approximately 20% of tert-butyl (5-nitropyrimidin-2- yl)dicarbamate mixture. Was used in the next step without purification).HPLC-MS (method A): Rt= 2.83 mm, [M+H] m/z: 241.Yield: 78%.General procedure: 4-Nitrophenyl Wang resin I (0.5 g; 0.41 mmol; 0.81 mmol/g) in dry DCM (10 mL), and
Computed Properties
Molecular Weight:140.10
XLogP3:-0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Exact Mass:140.03342538
Monoisotopic Mass:140.03342538
Topological Polar Surface Area:97.6
Heavy Atom Count:10
Complexity:126
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Amino-5-nitropyrimidine
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Business licensed Certified factoryManufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED IntermediatesInquiryCAS No.: 3073-77-6Grade: Pharmaceutical GradeContent: 99%
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