5-Methyloxindole
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5-Methyloxindole
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CAS No:
3484-35-3
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Formula:
C9H9NO
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Chemical Name:
5-Methyloxindole
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Synonyms:
2H-Indol-2-one,1,3-dihydro-5-methyl-;2-Indolinone,5-methyl-;Oxindole,5-methyl-;1,3-Dihydro-5-methyl-2H-indol-2-one;5-Methyloxindole;5-Methyl-2-oxoindoline;5-Methyl-2-oxindole;5-Methyl-2-indolinone;5-Methyl-1,3-dihydro-2H-indol-2-one
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CAS No:
5-Methyloxindole Use and Manufacturing
Treatment of the 5-methyl-3-methylthio-2-oxindole with Raney Nickel, as described, gave the General procedure: Weigh isatin (0.8g, 5.4mmol), the first of which was added 0.3g of 80% hydrazine hydrate (10ml) and heated to 100 C under reflux, was added portionwise remaining 0.5g, 2h addition was completed the temperature was raised to 110 C reflux was continued for 4h, cooled to room temperature, concentrated hydrochloric acid was added dropwise 36% was adjusted to pH = 3, stirring was continued at room temperature for 12h, the solid by suction filtration, washed with water and precipitation to give a brown solid (0.44g, 61%).Under nitrogen protection, 0.5 mmol of raw