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N-[2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]acetamide

N-[2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]acetamide structure

CAS No:
119-96-0
Formula:
C11H14AsNO3S2
Chemical Name:
N-[2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]acetamide
Synonyms:
Acetamide,N-[2-hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]-;Benzenearsonous acid,3-acetamido-4-hydroxydithio-,cyclic (hydroxymethyl)ethylene ester;Benzenearsonous acid,3-acetamido-4-hydroxydithio-,(hydroxymethyl)ethylene ester;1-Propanol,2,3-dimercapto-,cyclic 2,3-ester with 3-acetamido-4-hydroxydithiobenzenearsonous acid;1,3,2-Dithiarsolane,acetamide deriv.;N-[2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]acetamide;2-(3′-Acetamido-4′-hydroxyphenyl)-1,3-dithia-2-arsacyclopentane-4-methanol;Arsthinol;Balarsen;Mercaptoarsenol;Arsthinenol
Categories:
Organic Chemistry > Arsenicals

Description

Arsthinol is a member of acetamides and an anilide.|Arsthinol (INN) is an antiprotozoal agent that was first synthesized by Ernst A.H. Friedheim in 1949 via the complexing of acetarsol with 2,3-dimercaptopropanol. It has since been demonstrated that the agent possesses activity against amoebas and yaws. Considered well tolerated when compared to other related trivalent organoarsenicals, arsthinol has even undergone recent studies as a potential anticancer agent.

N-[2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]acetamide Basic Attributes

Molecular Weight：

347.279

Exact Mass：

347.29

EC Number：

204-361-7

ATC Code：

P - Antiparasitic products, insecticides and repellents

HScode：

2924299090

Characteristics

PSA：

120

XLogP3：

0.95970

Melting Point：

164.5 °C

Toxicity

Toxicity Summary：

Oral,mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 980 mg/kg.

Drug Information

Drug Indication：

Antiprotozoal agent effective against amoebiasis and yaws.

Metabolism/Metabolites：

89% Hepatic

MeSH Entry Terms：

arsthinol

N-[2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]acetamide Use and Manufacturing

Pharmaceutic aid (vehicle, flavored); pharmaceutic F110aid (vehicle, sweetened).

Computed Properties

Molecular Weight:347.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:346.963105
Monoisotopic Mass:346.963105
Topological Polar Surface Area:120
Heavy Atom Count:18
Complexity:308
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Latest News on N-[2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]acetamide

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Guide of N-[2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]acetamide

Description
Basic Attributes
Characteristics
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Latest News
Learn More Other Chemicals

N-[2-Hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]acetamide

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