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Carbarsone

Carbarsone structure

Carbarsone 

structure
  • CAS No:

    121-59-5

  • Formula:

    C7H9AsN2O4

  • Chemical Name:

    Carbarsone

  • Synonyms:

    Arsonic acid,[4-[(aminocarbonyl)amino]phenyl]-;Arsanilic acid,N-carbamoyl-;Carbarsone;[4-[(Aminocarbonyl)amino]phenyl]arsonic acid;Amabevan;Ameban;Amebarsone;Amibiarson;Aminarson;Aminarsone;Aminoarson;Arsambide;p-Arsonophenylurea;p-Carbamidobenzenearsonic acid;4-Carbamylaminophenylarsonic acid;N-Carbamylarsanilic acid;Fenarsone;Histocarb;Leucarsone;p-Ureidobenzenearsonic acid;4-Ureidophenylarsonic acid;N-Carbamoylarsanilic acid;Carbarson;4-Ureidobenzenearsonic acid;Pentarsone;Amebarsene;Kutan;Carb-O-Sep;NSC 32868;8027-01-8

  • Categories:

    Organic Chemistry  >  Arsenicals

Description

White powder or solid.


Carbarsone appears as white powder or solid. (NTP, 1992)


Carbarsone appears as white powder or solid. (NTP, 1992)|[4-(carbamoylamino)phenyl]arsonic acid is a member of ureas.|Carbarsone is a compound used as an antiprotozoal drug for the treatment of histomoniasis (or blackhead disease) in addition to other infectious diseases in chicken and turkeys. It belongs to the organoarsenic group of chemical compounds and has antiamebic properties. It is also used as a food additive with the goal of increasing weight gain and controlling the occurrence of blackhead disease in chicken and turkeys.

Carbarsone Basic Attributes

260.08

260.08

204-484-6

8PK70TXE1T

759884|32868

3280

DTXSID4020246

2931900090

Characteristics

113

-0.48850

Carbarsone appears as white powder or solid. (NTP, 1992)

174 °C

1 to 10 mg/mL at 71.1° F (NTP, 1992)

Oral-rat LD50: 510 mg/kg; Celiac-rat LDL0: 1000 mg/kg

Thermal decomposition releases toxic nitrogen oxides and arsenic fumes

Slightly soluble in water.

Amides and Imides

An acidic salt of an amide. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Safety Information

UN 3465 6.1 / PGIII

The warehouse is low-temperature, ventilated and dry

Missing Phrase - N15.00950417-P261-P304 + P340 + P312-P403 + P233

H301 + H331-H410

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P273, P301+P310, P304+P340, P311, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 3280 datasheet. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material under ambient temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Toxicity

moderately toxic

Drug Information

SYMPTOMS: Symptoms associated with arsenic compounds include irritation of the gastrointestinal tract, nausea, vomiting and diarrhea. In extreme cases, there may be blood in the vomitus and stool, rapid weak pulse, collapse, coma and death. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

4-ureidobenzenearsonic acid

Carbarsone Use and Manufacturing

Methods of Manufacturing

It is derived from p-nitroaniline through diazotization, arsine, reduction and addition. 1. Diazotization Add p-nitroaniline to hydrochloric acid, stir to cool to -5°C, add sodium nitrite solution and react for 1h to obtain diazonium salt solution. 2. Arsenicization Add arsenic trioxide and sodium carbonate to water, stir and heat to 100°C to dissolve all, cool, add copper sulfate solution below 25°C, then add the diazonium salt solution prepared in the previous step to the prepared In the sodium arsenite solution containing copper sulfate, the reaction temperature is controlled below 25°C to obtain a p-nitrophenylarsinic acid solution. 3. For the reduction, adjust the pH of the p-nitrophenylarsinic acid solution to 2.8-3.2 with sulfuric acid, add iron powder and sodium chloride, and raise the temperature to 100°C to react. The reaction end point is when the pH reaches 9 or above. Then add liquid alkali and let stand for more than 3h. Filter, adjust the filtrate to 4.5 with sulfuric acid, add activated carbon, and decolor at 50-90℃. After filtration, the filtrate was adjusted to pH 2.8-3.2 with sulfuric acid, cooled to 10°C, filtered and washed to obtain p-aminophenylarsonic acid. 4. Addition Cool p-aminophenylarsonic acid with water to 10°C, add sodium isocyanate and stir for 2h. Add hydrochloric acid below 15°C to pH4-4.5. Then add activated carbon to decolorize and filter, the filtrate is added hydrochloric acid to pH 1-2, cooled to below 10 ℃, filtered, washed, and dried to obtain carbacoarsine.

Uses

insecticide, cholinesterase inhibitor

Computed Properties

Molecular Weight:260.08
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:259.977826
Monoisotopic Mass:259.977826
Topological Polar Surface Area:113
Heavy Atom Count:14
Complexity:256
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

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