3-Amino-4-methoxy-N-phenylbenzamide
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3-Amino-4-methoxy-N-phenylbenzamide
structure -
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CAS No:
120-35-4
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Formula:
C14H14N2O2
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Chemical Name:
3-Amino-4-methoxy-N-phenylbenzamide
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Synonyms:
Benzamide,3-amino-4-methoxy-N-phenyl-;p-Anisanilide,3-amino-;3-Amino-4-methoxy-N-phenylbenzamide;3-Amino-p-anisanilide;3-Amino-4-methoxybenzanilide;1-Amino-2-methoxybenzene-5-carboxylic acid phenylamide;NSC 50647;3-Amino-4-methoxy-N-phenylbenzoic acid amide;M 40 (pigment);M 40;N-Phenyl-3-amino-4-methoxybenzenecarboxamide
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CAS No:
3-Amino-4-methoxy-N-phenylbenzamide Basic Attributes
242.27
242.27
204-388-4
V5Y646AW8S
50647
DTXSID0051607
2924299090
Characteristics
64.4
2
DryPowder
1.1338 (rough estimate)
154-156°C
385.1°C (rough estimate)
174.3±25.1 °C
1.6419 (estimate)
1.67E-05mmHg at 25°C
Intravenous-Mouse LD50: 320 mg/kg
Flammable; burning produces toxic nitrogen oxide fumes
Safety Information
IRRITANT
36/37/38
26-36/37/39
CV7400000
Warehouse ventilated, low temperature and dry
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
Not Classified
3-Amino-4-methoxy-N-phenylbenzamide Use and Manufacturing
Method 1: It is a commonly used method in production. Using o-nitroanisole as raw material, the product is obtained by chloromethylation, hydrolysis, oxidation, acid chloride, condensation and reduction. . This method has a long process route, a long production cycle, and a low product yield. Method 2: The latest research method. Using p-chlorobenzoic acid as raw material, the product is obtained through methoxylation, nitrification, condensation and reduction. This method has short process route, high product yield and low cost. . Add 46.8g of p-chlorobenzoic acid, 250mL of methanol and 12g of TR-300 in the reactor, and reflux for 10h to obtain 41.5g of p-methoxybenzoic acid. Add it to the nitrator, add 166g of dichloroethane and 0.5g of sulfuric acid (98%) at the same time, add 19g of nitric acid (98%) dropwise at 45°C, add within 3h, continue the heat preservation reaction for 2h to obtain the nitration product 52.7g. Add it to the condensator, add 200mL of solvent and 40mL of aniline at the same time, warm up to (98±2)℃, add 30mL of thionyl chloride dropwise (finished within 30min), and continue the heat preservation reaction for 4h to obtain 70.0g of the condensation product. Add it to the reducer and add 350mL of sodium hydrosulfide solution (30%) at the same time, warm to (80±2)°C and react for 15h to obtain 51.8g of the final product.
Dyes, pharmaceuticals, and other organic chemicals.
Intermediates
Synthetic dye and pigment manufacturing|Benzamide, 3-amino-4-methoxy-N-phenyl-: ACTIVE
Computed Properties
Molecular Weight:242.27
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:242.105527694
Monoisotopic Mass:242.105527694
Topological Polar Surface Area:64.4
Heavy Atom Count:18
Complexity:277
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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3-Amino-4-methoxy-N-phenylbenzamide
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