Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, hydrochloride (1:1)
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Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, hydrochloride (1:1)
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CAS No:
3778-76-5
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Formula:
C11H12N4O2.ClH
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Chemical Name:
Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, hydrochloride (1:1)
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Synonyms:
Hydrazinecarboxylic acid,2-(1-phthalazinyl)-,ethyl ester,hydrochloride (1:1);Carbazic acid,3-(1-phthalazinyl)-,ethyl ester,monohydrochloride;Hydrazinecarboxylic acid,2-(1-phthalazinyl)-,ethyl ester,monohydrochloride;Binazine;Binazin;N-Carbethoxy-N′-phthalazinohydrazide hydrochloride;2-Carbethoxy-1-(1-phthalazinyl)hydrazine hydrochloride;N1-Carboethoxy-N1-hydrazinophthalazine;Apirachol;Apiracohl;Ecarazine hydrochloride;Ecarazine;Todralazine hydrochloride;N-Carbethoxy-N′-(1-phthalazino)hydrazine hydrochloride;Apredor;Illcut;CEPH;Atapren;Propat;Apride;BT 621
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CAS No:
Description
Todralazine hydrochloride (Ecarazine hydrochloride) is an anti-hypertensive agent, acts as a β2AR blocker, with antioxidant and free radical scavenging activity[1].
An antihypertensive agent with both central and peripheral action; it has some central nervous system depressant effects.
Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, hydrochloride (1:1) Basic Attributes
268.7
268.07300
C59540FEXP
757868
DTXSID4044664
2933990090
Characteristics
76.14000
2.96870
1.328g/cm3
LD50 i.p. in mice: 500 mg/kg (Parravincini)
150 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
3
20/21/22
36
FE2778600
Xn
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)
Apirachol
Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, hydrochloride (1:1) Use and Manufacturing
Antihypertensor
Computed Properties
Molecular Weight:268.70
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:268.0727034
Monoisotopic Mass:268.0727034
Topological Polar Surface Area:76.1
Heavy Atom Count:18
Complexity:262
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, hydrochloride (1:1)
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