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Phloroglucinol

Phloroglucinol structure

CAS No:
108-73-6
Formula:
C6H6O3
Chemical Name:
Phloroglucinol
Synonyms:
1,3,5-Benzenetriol;Phloroglucinol;Benzene-s-triol;Phloroglucin;sym-Trihydroxybenzene;1,3,5-Trihydroxybenzene;Phloroglucine;Dilospan S;Spasfon-Lyoc;NSC 1572;3,5-Dihydroxyphenol;2,4,6-Benzenetriol
Categories:
Cosmetic Ingredient > Hair Dyeing

Description

white to light yellow crystalChEBI: A benzenetriol with hydroxy groups at position 1, 3 and 5.This product is a white or light yellow crystal or crystalline powder with melting point of 218 ℃. Usually it carries two molecular crystallization water ([6099-90-7]) and converts into anhydrous at 110 ℃. It can be dissolved in 100 parts of water, 10 parts of ethanol, and 0.5 parts of pyridine and is soluble in ether. Besides It partially decomposes when sublimation, and changes its color when exposed

Solid

Phloroglucinol is a benzenetriol with hydroxy groups at position 1, 3 and 5. It has a role as an algal metabolite.|Phloroglucinol has been used in trials studying the diagnostic of Colonoscopy.|A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.

Phloroglucinol Basic Attributes

Molecular Weight：

126.11000

Exact Mass：

126.11

EC Number：

203-611-2

UNII：

DHD7FFG6YS

NSC Number：

1572

DSSTox ID：

DTXSID9048354

ATC Code：

A - Alimentary tract and metabolism

HScode：

2907299090

Characteristics

PSA：

60.69000

XLogP3：

0.80340

Appearance：

Solid

Density：

1.488g/cm3

Melting Point：

218.5 °C

Boiling Point：

331.1ºC at 760 mmHg

Flash Point：

174.9ºC

Refractive Index：

n20/D 1.365

Water Solubility：

soluble in diethyl ether, ethanol and pyridine.

Storage Conditions：

Dark Room

Vapor Pressure：

8.27E-05mmHg at 25°C

Toxicity：

LD50 in mice, rats (g/kg): 4.7, 4.0 i.g. (Cahen)

Safety Information

Transport codes：

UN 1170 3/PG 2

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S24/25

RTECS Number：

SY1050000

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H315-H317-H319-H335

GHS Classification：

|Warning|H315 (85.29%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P261, P264, P271, P272, P273, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 104 companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)

Metabolism/Metabolites：

Phloroglucinol is a known human metabolite of 2-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one and Epicatechin.

MeSH Entry Terms：

1,3,5-Benzenetriol

Phloroglucinol Use and Manufacturing

Uses

Substance is used in diazo-type printing, textile dyeing.

Manufacturing Info：

1,3,5-Benzenetriol: ACTIVE

Use Classification：

Cosmetics -> Hair dyeing

Computed Properties

Molecular Weight:126.11
XLogP3:0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Exact Mass:126.031694049
Monoisotopic Mass:126.031694049
Topological Polar Surface Area:60.7
Heavy Atom Count:9
Complexity:63.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Resorcinol

Phenol

4-Aminophenol

Carbon dioxide

1-Methyl-4-nitrosobenzene

Acetic acid

Acetone

Hydrochloric acid

Sulfuric acid

Downstream Products

Resorcinol

Cyclohexanol

Phenol

Cyclohexane

Catechol

Benzene

Drug Function and Efficacy

1. It acts directly on the smooth muscles of the gastrointestinal tract and urogenital tract. It is a myotropic, non-atropine, non-opioid pure smooth muscle spasmolytic drug. 2. It does not have anticholinergic effects. While relieving smooth muscle spasms, it will not produce a series of anticholinergic effects. 3. It will not cause symptoms such as hypotension, increased heart rate, arrhythmia, and has no effect on cardiovascular function. 4. It only acts on spasmodic smooth muscles and has little effect on normal smooth muscles. 5. Subacute toxicity and long-term toxicity tests show that it has no adverse effects on animal growth, macroscopic and microscopic histology of important organs, blood and biochemical indicators. 6. Special toxicity test studies have shown that phloroglucinol is not teratogenic or mutagenic (carcinogenic).

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Phloroglucinol injection
Ingredients	The main ingredient of this product is phloroglucinol
Indication	Avoid concomitant use with morphine and its derivatives due to their spasmodic effects.
Specifications	4ml:40mg (calculated as phloroglucinol)
Manufacturer	Wuhan Humanwell Pharmaceutical Co., Ltd.

Phloroglucinol

Phloroglucinol for injection
Ingredients	Chemical name: 1,3,5-trihydroxybenzene dihydrate. Chemical structure: Molecular formula: C6H603·2H2O Molecular weight: 162.14 Excipients: Mannitol.
Indication	Avoid concomitant use with morphine and its derivatives due to their spasmodic effects.
Specifications	40 mg
Manufacturer	Hubei Wushi Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Porton Pharma Solutions Ltd.

China
Active
Sichuan Yinodabo Pharmaceutical Technology Co., Ltd.

China
Active
Shanxi Yanghe Pharmaceutical Co., Ltd.

China
Active

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