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(+)-Cepharanthine

(+)-Cepharanthine structure

CAS No:
481-49-2
Formula:
C37H38N2O6
Chemical Name:
(+)-Cepharanthine
Synonyms:
1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2′,3′:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-,(14aS,26aR)-;Cepharanthine;Oxyacanthan,6′,12′-dimethoxy-2,2′-dimethyl-6,7-[methylenebis(oxy)]-;(14aS,26aR)-2,3,13,14,14a,15,26,26a-Octahydro-22,30-dimethoxy-1,14-dimethyl-1H-4,6:16,19-dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2′,3′:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline;O-Methylcepharanoline;Cepharanthin;1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2′,3′:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-,[14aS-(14aR*,26aS*)]-;Cepharantin;(+)-Cepharanthine;NSC 623442;SML 1269;1413-58-7;30255-28-8
Categories:
Active Pharmaceutical Ingredients > Blood System Drugs

Description

Cepharanthine, an alkaloid derived from Stephania cepharantha Hayata, with possesses anti-inflammatory and antioxidative activities[1][2][3]. Cepharanthine attenuates muscle and kidney injuries induced by limb ischemia/reperfusion (I/R)[3]. Cepharanthine induces autophagy, apoptosis and cell cycle arrest in breast cancer cells[4]. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity[5].

Cepharanthine is a bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. It is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.

(+)-Cepharanthine Basic Attributes

Molecular Weight：

606.71

Exact Mass：

606.71

UNII：

7592YJ0J6T

NSC Number：

758965

DSSTox ID：

DTXSID6045957

Characteristics

PSA：

61.9

XLogP3：

6.5

Appearance：

Yellow powder.

Density：

1.2±0.1 g/cm3

Melting Point：

140-145 °C

Refractive Index：

1.608

Storage Conditions：

Store cool and dry in sealed containers.

Toxicity：

Oral-rat LD50: 2000 mg/kg; Oral-Mouse LD50: 1900 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic nitrogen oxide fumes

Specific rotation：

D20 +277° (c = 2 in chloroform)

Safety Information

Transport codes：

NONH for all modes of transport

RTECS Number：

FK0527000

Storage features：

The warehouse is low-temperature, ventilated and dry

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)|Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other purposes, e.g. military. (See all compounds classified as Radiation-Protective Agents.)

MeSH Entry Terms：

cepharanthin

(+)-Cepharanthine Use and Manufacturing

antineoplastic, hepatoprotectant, radiopropective

Computed Properties

Molecular Weight:606.7
XLogP3:6.5
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:606.27298694
Monoisotopic Mass:606.27298694
Topological Polar Surface Area:61.9
Heavy Atom Count:45
Complexity:994
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Stephania tetrandra tablets
Ingredients	Stephania truncatula.
Indication	Not yet clear.
Specifications	Each tablet weighs 0.05g (containing 20mg of cephalaenopsis)
Manufacturer	Yunnan Baiyao Group Wenshan Qihua Co., Ltd.

Stephania quinine
Manufacturer	BESTWAY Pharmaceutical Co., Ltd.

Stephania tetrandra tablets
Ingredients	Stephania truncatula.
Indication	Not yet clear.
Specifications	Each tablet weighs 0.05g (containing 20mg of cephalaenopsis)
Manufacturer	Shenyang Guancheng Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

BESTWAY Pharmaceutical Co., Ltd.

China
Active

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