2-(Methylamino)ethanol

75.10970

75.11

203-710-0

ZMQ4G4V497

1336

62776

3267|2735

DTXSID5025603

Viscous liquid|Clear colorless liquid|Colorless to light yellow liquid

29221980

32.26000

-0.41100

Methylethanolamine appears as a clear colorless liquid. Flash point 165°F. Less dense than water and soluble in water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used to make other chemicals.

0.937 g/cm³ @ Temp: 20 °C

-4.5 °C

155-156 °C @ Press: 760 Torr

72ºC

1.438-1.44

Micible with water.

Store in a cool, dry place. Do not store in direct sunlight. Keep container closed when not in use. Corrosives area.

0.5 mm Hg ( 20 °C)

2.6 (vs air)

LD50 orally in Rabbit: 1391 mg/kg LD50 dermal Rabbit 1006 mg/kg

vol% in air: 0.9.6

Fishy

A strong base

Henry's Law constant = 8.1X10-10 atm-cu/mol at 25 °C (est)

pKa = 9.95 at 20 °C

Forms deliquescent salt with HCl|Hydroxyl radical reaction rate constant = 7.9X10-11 cu cm/molec-sec at 25 °C (est)

Soluble in water.

Alcohols and Polyols

METHYLETHANOLAMINE is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. This compound may react with oxidizing materials. (NTP, 1992)

350 °C

-12,710 BTU/lb = -7060 cal/g at 25 °C

Corrosive to cork, metals

564 kJ/kg

Critical temperature: 630 deg K (est); critical pressure: 5.22 MPa (est)

III

8

UN 2735

1

R21/22; R34

S26-S36/37/39-S45

KL6650000

C

Separated from strong oxidants and acids.

Stable. Combustible. Incompatible with oxidizing agents.

P280-P301 + P312 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

H302 + H312-H314-H335-H373

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.|Product: This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company; Contaminated packaging: Dispose of as unused product.

Incompatible materials: Oxidizing agents, copper, zinc, iron. Do not store near acids.|Flammable when exposed to heat flame or oxidizing materials.|The substance is a strong base. It reacts violently with acid and is corrosive. Reacts with strong oxidants. Attacks many metals.|Corrosive to cork, metals.

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as nitrogen oxides and carbon monoxide, may be formed when involved in fire. (USCG, 1999)|Combustible. Above 74 °C explosive vapour/air mixtures may be formed.|Corrosives, Flammable - 2nd degree

|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P405, and P501|H302 (99.97%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 3100 companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P210, P260, P261, P264, P270, P271, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P314, P321, P322, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501|P210, P260, P264, P270, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P314, P321, P322, P363, P370+P378, P403+P235, P405, and P501

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Full impervious protective clothing, including boots and gloves. Where splashing is possible wear full face shield or chemical safety goggles. Use approved respirator to protect against vapors. (USCG, 1999)|Eye/face protection: Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves.|Body Protection: Complete suit protecting against chemicals. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Flammable when exposed to heat, flame, or oxidizers.

Above 74 °C explosive vapor/air mixtures may be formed.|Explosive limits, vol% in air: 0.9-2.6|Explosive limits , vol% in air: 0.9-2.6

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.|Use water spray to cool unopened containers.|To fight fire, used alcohol foam.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.|Collect leaking and spilled liquid in sealable containers as far as possible. Cautiously neutralize remainder. Then wash away with plenty of water.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.|Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.|Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.|SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Direct contact may cause skin and eye irritation, skin corrosion.

Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Cautiously neutralize remainder. Then wash away with plenty of water.

Separated from strong oxidants and acids.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is corrosive to the eyes, skin and respiratory tract.

NO open flames. Above 74 °C use a closed system and ventilation.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

2-Methylaminoethanol has been detected in tobacco, but not in tobacco smoke or substituted tobacco smoke(1).

IDENTIFICATION AND USE: 2-Methylaminoethanol is a viscous liquid. It is used in the manufacture of textile chemicals, pharmaceuticals. HUMAN EXPOSURE AND TOXICITY: Prolonged hematuria, pathologic liver function tests, and multiple skin warts described in a patient after 2-methylaminoethanol exposure. ANIMAL STUDIES: In rats it was irritating to the skin, eyes, and mucous membranes. 2-Methylaminoethanol (150 ppm) was not maternally toxic or embryotoxic in rats. It was not mutagenic in S. typhimurium TA 1535, TA 1537, TA 98 and TA 100 with and without metabolic activation.

LD50 Rat (male) oral 1908 mg/kg|LD50 Rat (female) oral 1391 mg/kg|LD50 Rabbit (male) dermal 1880 mg/kg|LD50 Rabbit (female) dermal 1006 mg/kg|For more Non-Human Toxicity Values (Complete) data for 2-Methylaminoethanol (10 total), please visit the HSDB record page.

2-Methylaminoethanol's production and use as an intermediate in the synthesis of numerous products that include coatings, textile lubricants, polishes, detergents, pesticides, personal care products, and pharmaceuticals(1) may result in its release to the environment through various waste streams(SRC). 2-Methylaminoethanol is reportedly used in hydraulic fracturing fluids which releases the compound directly to the environment(2).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 2-methylaminoethanol is expected to have very high mobility in soil(SRC). The pKa of 2-methylaminoethanol is 9.95(3), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of the neutral species of 2-methylaminoethanol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.1X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(2). 2-Methylaminoethanol is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.08 mm Hg at 25 °C(5). A 68% of theoretical BOD using activated sludge in the Japanese MITI test classifies 2-methylaminoethanol as readily biodegradable(6) and suggests that biodegradation is an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 2-methylaminoethanol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 8.1X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). The pKa of 2-methylaminoethanol is 9.95(4), indicating that this compound will exist almost entirely in cation form in the environment, and volatilization from water is unlikely since cations do not volatilize(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of -0.94(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 68% of theoretical BOD using activated sludge in the Japanese MITI test classifies 2-methylaminoethanol as readily biodegradable(7) and suggests that biodegradation is an important environmental fate process in water(SRC). Hydrolysis is not expected to be an important environmental fate process(SRC) since this compound lacks functional groups that hydrolyze under environmental conditions(3).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-methylaminoethanol, which has a vapor pressure of 1.08 mm Hg at 25 °C (2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-methylaminoethanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.9 hours(SRC), calculated from its rate constant of 7.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 2-Methylaminoethanol does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight(4).

The rate constant for the vapor-phase reaction of 2-methylaminoethanol with photochemically-produced hydroxyl radicals has been estimated as 7.9X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 4.9 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(SRC). 2-Methylaminoethanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 2-Methylaminoethanol does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight(1).

An estimated BCF of 3 was calculated in fish for 2-methylaminoethanol(SRC), using a log Kow of -0.94(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 2-methylaminoethanol can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-methylaminoethanol is expected to have very high mobility in soil. The pKa of 2-methylaminoethanol is 9.95(3), indicating that this compound will exist almost entirely in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

The Henry's Law constant for 2-methylaminoethanol is estimated as 8.1X10-10 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 2-methylaminoethanol is expected to be essentially nonvolatile from water surfaces(2). The pKa of 2-methylaminoethanol is 9.95(3), indicating that this compound will exist almost entirely in cation form in the environment, and volatilization from water applies to the neutral species since cations do not volatilize(SRC). 2-Methylaminoethanol's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected to occur for the neutral species(SRC). 2-Methylaminoethanol is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.08 mm Hg at 25 °C(4).

According to the 2012 TSCA Inventory Update Reporting data, 7 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of 2-methylaminoethanol in the United States may be as low as <10 workers and as high as 50-99 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 39,013 workers (11,887 of these are female) are potentially exposed to 2-methylaminoethanol in the US(1). Occupational exposure to 2-methylaminoethanol may occur through inhalation and dermal contact with this compound at workplaces where 2-methylaminoethanol is produced or used(2). 2-Methylaminoethanol is used only for industrial application and is not sold for direct consumer use(2).

In vivo precursor of choline.|The incorporation of the phosphate ester of 2-methylaminoethanol into phospholipids of brain and liver suspensions was observed.

Exposure can cause irritation of eyes, nose and throat. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/amines and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/amines and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. If patient is unresponsive to these measures, vasopressors may be helpful. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organic bases/amines and related compounds/

/SIGNS AND SYMPTOMS/ /Inhalation causes:/ sore throat, cough, burning sensation, shortness of breath, labored breathing, symptoms may be delayed.|/SIGNS AND SYMPTOMS/ /Skin exposure causes/ pain, redness, blisters, skin burns.|/SIGNS AND SYMPTOMS/ /Eye exposure causes/ pain, redness, severe deep burns, loss of vision.|/SIGNS AND SYMPTOMS/ /Ingestion causes/ burning sensation, abdominal pain, shock or collapse.|/CASE REPORTS/ ... This report presents a patient who during exposure to 2-methylaminoethanol developed prolonged hematuria, pathologic liver function tests, and multiple skin warts.

2-methylaminoethanol

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Sore throat. Cough. Burning sensation. Shortness of breath. Laboured breathing. Symptoms may be delayed.

Pain. Redness. Blisters. Skin burns.

Pain. Redness. Severe deep burns. Loss of vision.

All other basic organic chemical manufacturing|Ethanol, 2-(methylamino)-: ACTIVE

Fire Hazards -> Corrosives, Flammable - 2nd degree|Cosmetics -> Buffering