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Home > Encyclopedia > Glucono Delta Lactone

Glucono Delta Lactone

pharmaceutical raw materials
Glucono Delta Lactone structure

Glucono Delta Lactone 

structure
  • CAS No:

    90-80-2

  • Formula:

    C6H10O6

  • Chemical Name:

    Glucono Delta Lactone

  • Synonyms:

    D-Gluconic acid,δ-lactone;Gluconic acid,δ-lactone,D-;Gluconic acid lactone;Gluconic acid,lactone,D-;D-Glucono-1,5-lactone;D-Gluconic acid 1,5-lactone;1,5-Gluconolactone;δ-Gluconolactone;D-(+)-Gluconic acid δ-lactone;D-Glucono-δ-lactone;D-(+)-Glucono-δ-lactone;D-Gluconic acid lactone;Gluconolactone;glucono delta lactone;Fujiglucon;E 575;D-(+)-Glucono-1,5-lactone;Lysactone;Riken Lactone;D-(+)-Glucose δ-lactone;Glucono-δ-lactone;(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one;1,5-D-Gluconolactone;(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)oxan-2-one;1335-57-5;4253-68-3;71033-49-3;302547-96-2;1020398-69-9;1025765-61-0;1245945-89-4;1542210-74-1

  • Categories:

    Cosmetic Ingredient  >  Skin Conditioning

Description

D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.

Glucono Delta Lactone Basic Attributes

178.14000

178.14

202-016-5

758238

2932999099

Characteristics

107.22000

-2

Powder

1.610 g/cm3 @ Temp: -5 °C

153 °C

446.4ºC at 760 mmHg

192.3ºC

63.5 ° (C=10, H2O)

H2O: 500 g/L (20 ºC)

Refrigerator

2.8X10-9 mm Hg at 25 deg (est)

Specific optical rotation = +63.5 deg to +6.2 deg at 25 °C (solvent= water) mutarotatory

Sweet taste

Freshly prepared aqueous solution has pH of 3.6, changing to 2.5 within 2 hours

Safety Information

NONH for all modes of transport

3

R21

S24/25

LZ5184000

Xn; Xi

P264, P280, P305+P351+P338, P33, P313

H319

Glucono Delta Lactone Use and Manufacturing

Methods of Manufacturing

1. Raw calcium gluconate hydrolysis with sulfuric acid, in gluconic acid solution. The calcium sulfate precipitate is removed by filtration, and the solution is refined by barium hydroxide and oxalic acid, and the solution is separated and sedimentated to remove SO42- and Ca2 + in solution. The gluconic acid solution is then further purified by ion exchange resin. Concentrating the solution to 80-85% concentration, adding glucono-delta-lactone seeds, concentrating and crystallizing, and then centrifuging; washing with water; drying to obtain finished product.
2. Calcium gluconate first hydrolysis with sulfuric acid, in gluconic acid solution. The calcium sulfate precipitate is removed by filtration, and the solution is refined by barium hydroxide and oxalic acid, and the solution is separated and sedimentated to remove SO42- and Ca2 + in the solution. The gluconic acid solution is then further purified by ion exchange resin. Concentrating the solution to 80-85 percent, adding gluconic acid δ-lactone seeds, concentrating and crystallizing, centrifugally separating, washing and drying.

Uses

1. Geogard(R)Ultra is a synergistic blend of gluconolactone and sodium benzoate. This blend provides broad spectrum protection against product spoilage in a variety of personal care formulations. Product Data Sheet
2. A lactone (cyclic ester) of D-gluconic acid used as a used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent.
3. Chelating agent
4. D-glucono-1,5-lactone is the lactone derivative of D-gluconic acid. D-glucono-1,5-lactone is widely used as a food additive to achieve a curing, pickling or leavening effect.
5. A product of the oxidation of glucose by glucose oxidase

Computed Properties

Molecular Weight:178.14
XLogP3:-2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:178.04773803
Monoisotopic Mass:178.04773803
Topological Polar Surface Area:107
Heavy Atom Count:12
Complexity:181
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Downstream Products

Drug Function and Efficacy

Moisturizes, exfoliates gently, improves skin texture and tone, provides antioxidant benefits and supports skin barrier function

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • INNER MONGOLIA BAIYI Pharmaceutical Co., Ltd.

    China China
    Active
  • Hebei Zhaoyao New Material Co., Ltd.

    China China
    Inactive
  • Anhui Xingzhou Pharmaceutical Co., Ltd.

    China China
    Inactive

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