Sulfapyridine

249.29

249.29

205-642-7

Y5V2N1KE8U

757329|41791|4753

DTXSID3026067

C66570

J - Antiinfectives for systemic use

29350010

93.5

0

Sulfapyridine appears as odorless or almost odorless white or yellowish-white crystalline powder. Very slightly bitter taste. Aqueous solution is neutral. (NTP, 1992)

1.3220 (rough estimate)

192 °C

473.5±51.0 °C(Predicted)

240.2±30.4 °C

1.6740 (estimate)

H2O: <0.1 g/100 mL at 22 ºC

2-8°C

3.9E-09mmHg at 25°C

LD50 orally in mice: 7.5 mg/g (Wien)

8.43None

8.43

150.8 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|151.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|142.3 Ų [M+H]+ [CCS Type: TW]|154.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]|163.9 Ų [M+Na]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]|156.54 Ų [M-H]-

Insoluble in water.

Amines, Phosphines, and Pyridines

SULFAPYRIDINE is an amino acid. Slowly darkens on exposure to light (NTP, 1992). Soluble in both acidic and basic aqueous solutions

IRRITANT

NONH for all modes of transport

2

36/37/38

22-24/25-36-26

DA9625000

Xi

Stable. Combustible. Protect from light. Incompatible with strong oxidizing agents.

P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P309+P311, P312, P321, P330, P332+P313, P337+P313, P362, P405, P501

H302

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

LD50 is 15800 mg/kg (orally in rats).

Approximately 50% bound to plasma proteins.

For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum

Sulfapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)|Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)

Approximately 60-80%

Hepatic.|Sulfapyridine has known human metabolites that include Sulfapyridine, N-acetyl.

6-14 hours.

Sulfapyridine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid by means of processing the substrate para-aminobenzoic acid (PABA). Dihydropteroate synthetase activity is vital in the synthesis of folate, and folate is required for cells to make nucleic acids, such as DNA or RNA. So if DNA molecules cannot be built, the cell cannot divide.

SYMPTOMS: Symptoms of exposure to this compound include fever, rash, agranulocytosis, deposition of crystals in the urinary tract with consequent hematuria or anuria, nausea, vomiting, cyanosis, sensitization and, rarely, granulocytopenia. Other symptoms include acute transient myopia, conjunctivitis, keratitis, disturbances of the optic nerve and retina, temporary impairment of depth perception, swelling of the eyelids, photophobia, lacrimation, Stevens-Johnson syndrome, Lyell syndrome, amblyopia, central scotoma and optic neuritis, usually with papilledema. It can induce crystalluria. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes of nitrogen oxides and sulfur oxides. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Sulfapyridine

Pharmaceutical and medicine manufacturing|Benzenesulfonamide, 4-amino-N-2-pyridinyl-: ACTIVE

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Pharmaceuticals -> Animal Drugs -> Approved in Taiwan