20α-Dihydroprogesterone
-
20α-Dihydroprogesterone
structure -
-
CAS No:
145-14-2
-
Formula:
C21H32O2
-
Chemical Name:
20α-Dihydroprogesterone
-
Synonyms:
Pregn-4-en-3-one,20-hydroxy-,(20S)-;Pregn-4-en-3-one,20α-hydroxy-;(20S)-20-Hydroxypregn-4-en-3-one;20α-Dihydroprogesterone;20α-Hydroxydihydroprogesterone;20α-Hydroxy-Δ4-pregnen-3-one;20α-Hydroxy-4-pregnen-3-one;20α-Hydroxyprogesterone;Pregn-4-ene-20α-ol-3-one;Δ4-Pregnene-20α-ol-3-one;Pregn-4-en-20α-ol-3-one;20α-Progerol;20α-Hydroxypregn-4-en-3-one;20-Hydroxypregn-4-en-3-one;Progesterol-20α;4-Pregnen-3-one-20α-ol;20(S)-Hydroxyprogesterone;Δ4-Pregnen-20α-ol-3-one;NSC 68630
-
CAS No:
Description
Solid
(20S)-20-hydroxypregn-4-en-3-one is a 20-hydroxypregn-4-en-3-one. It has a role as a human metabolite and a mouse metabolite.|A biologically active 20-alpha-reduced metabolite of PROGESTERONE. It is converted from progesterone to 20-alpha-hydroxypregn-4-en-3-one by the 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE in the CORPUS LUTEUM and the PLACENTA.
Characteristics
37.30000
4.51530
Solid
1.13 g/cm3
171-172 °C
451.7±14.0 °C(Predicted)
192.4ºC
1.549
4.65E-10mmHg at 25°C
Safety Information
3
TU5559900
P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, P501
H302
Drug Information
Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY. (See all compounds classified as Progestins.)
20 alpha Dihydroprogesterone
20α-Dihydroprogesterone Use and Manufacturing
Δ4-Pregnen-20α-ol-3-one is the main metabolite of Progesterone (P755900). Studies shows regulation of estrogen receptor levels in breast cancer by Δ4-Pregnen-20α-ol-3-one and other progesterone metabolites.
Lipids -> Sterol Lipids [ST] -> Steroids [ST02] -> C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]
Computed Properties
Molecular Weight:316.5
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:316.240230259
Monoisotopic Mass:316.240230259
Topological Polar Surface Area:37.3
Heavy Atom Count:23
Complexity:550
Defined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes