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Phenytoin

Phenytoin structure

CAS No:
57-41-0
Formula:
C15H12N2O2
Chemical Name:
Phenytoin
Synonyms:
2,4-Imidazolidinedione,5,5-diphenyl-;Hydantoin,5,5-diphenyl-;5,5-Diphenyl-2,4-imidazolidinedione;Denyl;Dihycon;Di-Lan;Dintoina;Diphantoin;Diphedan;Diphenylhydantoin;DPH;Hidantal;Lepitoin;Phenytoin;Sodanton;Zentropil;Aleviatin;Di-Hydan;Dilabid;Phenytoine;5,5-Diphenylhydantoin;Diphenylan;Lehydan;Hydantol;Ekko;NSC 8722;Diphenat;5,5-Diphenyl-1H-imidazolidine-2,4-dione;Phenytek;5,5-Diphenylimidazoline-2,4-dione;Phenytoinum;Phenytin;Ipanten;125-59-7;1061190-62-2
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Phenytoin is an inactive voltage-gated sodium channel stabilizer.Target: Sodium ChannelPhenytoin is an antiepileptic drug. It is useful to treat partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures. Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage-gated sodium channels [1]. Phenytoin has low affinity for resting sodium channels at hyperpolarized membrane po

Phenytoin Basic Attributes

Molecular Weight：

252.27

Exact Mass：

252.27

BRN：

384532

EC Number：

200-328-6

HScode：

2933990090

Characteristics

PSA：

58.2

XLogP3：

2.2

Appearance：

White to almost white Powder

Density：

1.26 g/cm³

Melting Point：

286 °C

Boiling Point：

464.0±55.0 °C at 760 mmHg

Flash Point：

11 °C

Refractive Index：

1.652

Water Solubility：

H2O: <0.01 g/100 mL at 19 ºC;DMSO: soluble

Storage Conditions：

2-8°C

Vapor Pressure：

1.2X10-10 mm Hg at 25 deg C (est)

Toxicity：

LD50 in mice (mg/kg): 92 i.v.; 110 s.c. (Stille, Brunckow)

Odor：

Odorless

PKA：

8.33None

Safety Information

Packing level：

Hazard category：

6.1(b)

Transport codes：

2811

wgk germany：

hazard class code：

45-61-22-63-40-39/23/24/25-23/24/25-11-20/21/22

safety instructions：

53-45-36/37-16-7

RTECS Number：

MU1050000

Marks：

T,Xn,F

Stability/Shelf Life：

Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.

Precautionary statement(s)：

P201-P308 + P313

Hazard Statements：

H302-H350-H360

Phenytoin Use and Manufacturing

A sodium channel protein inhibitor

Computed Properties

Molecular Weight:252.27
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:252.089877630
Monoisotopic Mass:252.089877630
Topological Polar Surface Area:58.2
Heavy Atom Count:19
Complexity:350
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Benzaldehyde

Chlorine dioxide

Urea

Benzene

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