10,10′-Oxybisphenoxarsine

502.225

502.23

200-377-3

1R0GEE9L5Z

1760|1557

DTXSID0032443

27.69000

2.82620

Phenoxarsine, 10,10'-oxydi- appears as a clear light yellow liquid with a mild odor. Insoluble in water and slightly denser than water. Contact may severely irritate skin, eyes, and mucous membranes.

1.40-1.42 g/cm³

184-185 °C

531.3±43.0 °C at 760 mmHg

214.1±28.1 °C

insoluble

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

5.1X10-12 mm Hg at 25 deg C (est)

LD50 orl-rat: 40 mg/kg TXCYAC 10,341,78

Odorless

Highly flammable. Insoluble in water.

Ethers

Highly Flammable

Organometallics, such as PHENOXARSINE, 10,10'-OXYDI-, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents.

II

6.1(a)

1557

P260, P261, P264, P270, P271, P273, P280, P284, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P312, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, P501

H300

(Non-Specific -- Arsenic Compounds) When heated to decomposition, it emits highly toxic fumes of arsenic. (EPA, 1998)

|Danger|H300 (73.4%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P273, P280, P284, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P312, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 94 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

(Non-Specific -- Arsenic Compound, Solid, n.o.s.) Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing. (Non-Specific -- Arsenic Compound, Solid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Move container from fire area if you can do so without risk. (EPA, 1998)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

(Non-Specific -- Arsenic Compounds) Arsenic compounds are acutely poisonous by ingestion. Ingestion or inhalation may result in chronic poisoning. Arsenic compounds are recognized carcinogens of the skin, lungs, and liver. (EPA, 1998)

Warning: Effects usually appear within 30 to 60 minutes, but may be delayed for a few hours. Arsenic compounds are recognized carcinogens of the skin, lungs, and liver. Caution is advised. Signs and Symptoms of Phenoxarsine, 10,10'-oxydi- Exposure: Signs and symptoms of acute exposure to phenoxarsine, 10,10'-oxydi may include dehydration, intense thirst, difficulty swallowing, nausea, vomiting, anorexia and abdominal pain. Headache, red conjunctival stains, and garlic breath are among the first signs and symptoms of poisoning. Exposure to airborne dust is generally accompanied by irritation of exposed skin, eyes, and mucous membranes. Conjunctivitis (red, inflamed eyes), runny nose, and lacrimation (tearing) are common. Pulmonary edema may also occur. Cardiovascular effects include shock, hypotension (low blood pressure), tachycardia (rapid heart rate), T-wave elevations, ventricular fibrillation, and other cardiac abnormalities. Jaundice and bronzing of the skin have been reported in severe hemolysis cases. Oliguria leading to anuria may result from hemoglobinuria; urine may become green or red in color. Altered mental status, seizures, and delirium are further complications of phenoxarsine, 10,10'-oxydi- exposure. Intense muscle cramping may be observed. Emergency Life-Support Procedures: Acute exposure to phenoxarsine, 10,10'-oxydi- may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to phenoxarsine, 10,10'-oxydi-. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Rush to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to phenoxarsine,10,10'-oxydi-. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Remove and isolate contaminated clothing and shoes as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas thoroughly with water. 6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 7. Rush to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. DO NOT induce vomiting. 4. Activated charcoal is of no value. 5. Rush to health care facility. (EPA, 1998)

10,10'-oxybisphenoxarsine oxide