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Rongalite

pharmaceutical raw materials
Rongalite structure

Rongalite 

structure
  • CAS No:

    149-44-0

  • Formula:

    CH4O3S.Na

  • Chemical Name:

    Rongalite

  • Synonyms:

    Methanesulfinic acid,1-hydroxy-,sodium salt (1:1);Sodium formaldehydesulfoxylate;Methanesulfinic acid,hydroxy-,monosodium salt;Formaldehyde sodium sulfoxylate;Formopan;Hydrolit;Hydroxymethanesulfinic acid sodium salt;Rongalit;Rongalit C;Rongalite;Rongalite C;Sodium hydroxymethanesulfinate;Sodium sulfoxylate formaldehyde;Sodium (hydroxymethyl)sulfinate;Formaldehydesulfoxylic acid sodium salt;Sodium methanalsulfoxylate;Aldanil;Formapon;Leptacid;C.I. Reducing Agent 2;Redol C;Rodite;Leptacit;Bleachit D;Superlite C;NSC 4847;NSC 78331;Cosmolit;Formaldehyde-sodium hydrogen sulfite;Langqielie C;Bruggolite E 01;Bruggolit E 01;Bruggolite SFS;Bruggolite C;Rongolite C;ST;ST (Rongalite);SFS;15193-20-1;15678-57-6;38563-80-3;59348-48-0;69346-14-1;134036-48-9;1085937-62-7;1129303-06-5

  • Categories:

    Organic Chemistry  >  Aldehydes

Description

DryPowder


DryPowder; DryPowder, Liquid; PelletsLargeCrystals

Rongalite Basic Attributes

118.09

117.97000

205-739-4

X4ZGP7K714

DTXSID7027120

HARD WHITE MASSES

2930909090

Characteristics

79.6

-0.31900

DryPowder; DryPowder, Liquid; PelletsLargeCrystals

63-64 °C

446.4ºC at 760mmHg

>100℃

H2O: 50 mg/mL, clear, colorless

Oral-Rat  LD50 > 2000  mg/kg; Oral-Mouse LD50: 4000 mg/kg

Combustible when heated, toxic formaldehyde gas

A moderate explosion hazard when exposed to heat or flame. /Formaldehyde/

Odorless when freshly prepd, but quickly develops a characteristic (garlic) odor; readily decomposed by diluted acids; aq soln is practically neutral; decomp @ high temp /dihydrate/

Safety Information

NONH for all modes of transport

1

36/37/38-68-31

26-36-36/37

PB0380000

Xi,Xn

Storeroom low temperature, ventilated, dry; fireproof; stored separately from oxidants, food ingredients

Heat, decomposition of formaldehyde in flames explodes

Stable. Incompatible with strong oxidizing agents.

P281

H341

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Sodium formaldehyde sulfoxylate is an indirect food additive for use only as a component of adhesives.

|Warning|H341 (95.07%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]|P201, P202, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 502 companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

A moderate explosion hazard when exposed to heat or flame. /Formaldehyde/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

A human skin and eye irritant. /Formaldehyde/

Toxicity

moderately toxic

LD50 Mouse oral 4 g/kg

Drug Information

/SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

If swallowed it causes violent vomiting & diarrhea that can lead to collapse. Frequent or prolonged exposure can cause hypersensitivity leading to contact dermatitis, possibly of an eczematoid nature. /Formaldehyde/

formaldehydesulfoxylate

Rongalite Use and Manufacturing

Methods of Manufacturing

Zinc powder sulfur dioxide formaldehyde method The slurry made of water and zinc powder reacts with sulfur dioxide gas to produce zinc hyposulfite, which is then gradually added to the second reactor pre-filled with formaldehyde solution. Under heating and stirring, the zinc powder is gradually added The reaction is carried out at 95~105°C to produce a formaldehyde suspension of basic zinc sulfoxylate, which is sent to the third reactor. The crystals are washed with water, and then left to stand. The clear liquid is extracted, and the caustic soda solution is added to react to generate hydrogen sulfoxylate. The suspension of sodium formaldehyde and zinc hydroxide is filtered, the filtrate is clarified, concentrated, crystallized, and crushed to obtain the finished product of sodium formaldehyde sulfoxylate.

Uses

Mainly used in printing and dyeing industry as discharge agent, color discharge agent, reducing agent and activator of styrene butadiene rubber and synthetic resin, also used for decolorization and bleaching of some organic substances (such as: synthetic rubber, sugar, food industry bleaching) Agent), can be used instead of insurance powder under certain specific conditions.


Catalyst used in the polymerization process


Polymer production process

Production

1,000,000 - 10,000,000 lb

Purity: usually admixed with sulfite. /dihydrate/

Paint and coating manufacturing|Methanesulfinic acid, 1-hydroxy-, sodium salt (1:1): ACTIVE|/PRC: CAN REDUCE IN VITRO/...CORROSIVE MERCURIC CHLORIDE TO INSOL MERCUROUS SALTS, OR METALLIC MERCURY. ALSO USED AS AN ANTIOXIDANT IN PARENTERAL FORMULATIONS.|Limited value in treatment of murcuric chloride poisoning; /PRC: This observation is not substantiated, only occurs in vitro/

HYDROXYMETHANESULFINATE AND ITS DECOMP PRODUCTS SUCH AS FORMALDEHYDE, ZN AND SULFITES CAN BE DETERMINED QUANTITATIVELY IN EACH OTHER'S PRESENCE BY A POLAROGRAPHIC METHOD.

Computed Properties

Molecular Weight:118.09
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:117.97005941
Monoisotopic Mass:117.97005941
Topological Polar Surface Area:79.6
Heavy Atom Count:6
Complexity:46.1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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