L-Hydroxyproline
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L-Hydroxyproline
structure -
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CAS No:
51-35-4
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Formula:
C5H9NO3
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Chemical Name:
L-Hydroxyproline
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Synonyms:
L-Proline,4-hydroxy-,(4R)-;Proline,4-hydroxy-,L-;L-Proline,4-hydroxy-,trans-;(4R)-4-Hydroxy-L-proline;Hydroxy-L-proline;4-Hydroxyproline;4(R)-Hydroxy-2(S)-pyrrolidinecarboxylic acid;Hypro;δ-Hydroxyproline;4-Hydroxy-L-proline;trans-4-Hydroxyproline;Hydroxyproline;trans-4-Hydroxy-L-proline;trans-L-Hydroxyproline;4-trans-Hydroxy-L-proline;L-4-Hydroxyproline;Ls-Hydroxyproline;(2S,4R)-(-)-4-Hydroxyproline;L-Hydroxyproline;L-trans-4-Hydroxyproline;(R)-4-Hydroxy-(S)-proline;(S)-Hydroxyproline;L-Hypro;(-)-4-Hydroxy-2-pyrrolidinecarboxylic acid;trans-L-4-Hydroxyproline;(R)-4-Hydroxy-L-proline;Proline,4-hydroxy-;(2S,4R)-4-Hydroxyproline;NSC 46704;4-Hydroxy-(S)-proline;4(R)-Hydroxyproline;(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid;(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid;(4R,2S)-Hydroxyproline;trans-(2S,4R)-4-Hydroxy-L-proline;138-46-5;17210-41-2;21105-75-9;24784-87-0;54733-36-7
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CAS No:
Description
L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
Characteristics
69.56000
-3.3
Solid
1.395 g/cm3
274 °C
355.2ºC at 760 mmHg
168.6ºC
-75.5 ° (C=4, H2O)
H2O: 357.8 g/L (20 º C)
Store at RT.
pK1′ 1.82 and pK2′ 9.65
Safety Information
NONH for all modes of transport
3
R36/37/38
S24/25
TW3586500
Xi
Stable under normal temperatures and pressures.
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
L-Hydroxyproline Use and Manufacturing
1. A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.
2. A versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins.
Drug Function and Efficacy
An amino acid involved in collagen synthesis, contributing to skin firmness and repair.
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