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Haloperidol

Haloperidol structure

CAS No:
52-86-8
Formula:
C21H23ClFNO2
Chemical Name:
Haloperidol
Synonyms:
1-Butanone,4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-;Butyrophenone,4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4′-fluoro-;4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone;R 1625;4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone;γ-[4-(p-Chlorphenyl)-4-hydroxypiperidino]-p-fluorbutyrophenone;1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine;Haldol;Haloperidol;4-(4-Hydroxy-4′-chloro-4-phenylpiperidino)-4′-fluorobutyrophenone;Serenase;Serenace;Aloperidin;Serenelfi;Haloperin;Neurodol;Eukystol;Dozic;Peluces;Einalon S;Keselan;Sigaperidol;Brotopon;Halosten;Linton;Bioperidolo;McN-JR 1625;NSC 170973;NSC 615296
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

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Description

Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.

Haloperidol Basic Attributes

Molecular Weight：

375.86

Exact Mass：

375.86

EC Number：

200-155-6

HScode：

2933399090

Characteristics

PSA：

40.5

XLogP3：

3.2

Appearance：

white powder

Density：

1.2±0.1 g/cm3

Melting Point：

151.5 °C

Boiling Point：

529°C at 760 mmHg

Flash Point：

9℃

Refractive Index：

1.581

Water Solubility：

H2O: 14 g/100 mL (25 ºC);45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.39 mg/mL

Storage Conditions：

Store at RT

Vapor Pressure：

4.8X10-11 mm Hg @ 25 deg C /Estimated/

Toxicity：

LD50 orally in rats: 165 mg/kg (Goldenthal); i.p. in mice: 60 mg/kg (Collins, Horlington)

PKA：

8.66None

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

60-61-25-36/37/38-43-39/23/24/25-23/24/25-11

safety instructions：

53-26-36/37/39-45-36/37-16

RTECS Number：

EU1575000

Marks：

T,F

Stability/Shelf Life：

Stable at normal temperature and pressure.

Precautionary statement(s)：

P261-P280-P301 + P310-P305 + P351 + P338

Hazard Statements：

H301-H315-H317-H319-H335-H361

Haloperidol Use and Manufacturing

Methods of Manufacturing

It is obtained by condensation of 4-p-chlorobenzene-4-hydroxypiper (see 09670) with γ-chlorop-fluorobutanone. The intermediate γ-chlorofluorobutanone is prepared from fluorobenzene, γ-butyrolactone, and sulfoxide chloride (see 09060).

Uses

Antidyskinetic; antipsychotic

Computed Properties

Molecular Weight:375.9
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:375.1401348
Monoisotopic Mass:375.1401348
Topological Polar Surface Area:40.5
Heavy Atom Count:26
Complexity:451
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Thionyl chloride

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Haloperidol

Haloperidol Tablets
Ingredients	The main ingredient of this product is haloperidol, and its chemical name is: 1-(4-fluorophenyl)-4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-butanone.
Indication	1 When this product is used in combination with ethanol or other central nervous system depressants, the central nervous system depressant effect is enhanced. 2 When this product is used in combination with amphetamine, the effect of the latter can be reduced. 3 When this product is used in combination with barbiturates or other anticonvulsants: it can change the form of epileptic seizures; it cannot enhance the efficacy of anticonvulsants. 4 When this product is used in combination with antihypertensive drugs, severe hypotension can occur. 5 When this product is used in combination with anticholinergic drugs, it may increase intraocular pressure. 6 When this product is used in combination with adrenaline, due to the blocking of alpha receptors, the activity of beta receptors becomes dominant, which can lead to a decrease in blood pressure. 7 When this product is used in combination with lithium salts, attention should be paid
Specifications	2mg
Manufacturer	Baishan Changbaishan Pharmaceutical Co., Ltd.

Haloperidol Tablets
Ingredients	The main ingredient of this product is haloperidol, and its chemical name is: 1-(4-fluorophenyl)-4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-butanone.
Indication	1 When this product is used in combination with ethanol or other central nervous system depressants, the central nervous system depressant effect is enhanced. 2 When this product is used in combination with amphetamine, the effect of the latter can be reduced. 3 When this product is used in combination with barbiturates or other anticonvulsants: it can change the form of epileptic seizures; it cannot enhance the efficacy of anticonvulsants. 4 When this product is used in combination with antihypertensive drugs, severe hypotension can occur. 5 When this product is used in combination with anticholinergic drugs, it may increase intraocular pressure. 6 When this product is used in combination with adrenaline, due to the blocking of alpha receptors, the activity of beta receptors becomes dominant, which can lead to a decrease in blood pressure. 7 When this product is used in combination with lithium salts, attention should be paid
Specifications	2mg
Manufacturer	Beijing Taiyang Pharmaceutical Industry Co., Ltd.

See More Related Drugs

Registered Holders

MANKIND PHARMA LTD

United States
Active
VAMSI LABS LTD

United States
Active
MSN LIFE SCIENCES PRIVATE LTD

United States
Active

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