Methyl anthranilate

151.16300

151.16

205-132-4

981I0C1E5W

3109

DTXSID6025567

Crystals|Pale-yellow liquid with bluish fluorescence|Colorless to pale-yellow liquid or crystals with bluish fluorescence|Colorless to pale yellow liquid or solid

2922499990

52.32000

1.63660

Methyl anthranilate is a clear colorless to tan liquid with an odor of grapes. Has light blue fluorescence. (NTP, 1992)

1.168 g/cm³ @ Temp: 20 °C

24.5 °C

256 °C

104ºC

1.581-1.584

H2O: slightly soluble

Store in a cool, dry place. Keep container closed when not in use.

1 mm Hg ( 20 °C)

Not a fire or explosion hazard when stored under normal conditions. Closed containers may explode (due to the build-up of pressure) when exposed to extreme heat.

Grape-like odor

Slightly bitter, pungent

Henry's Law constant = 1.89X10-6 atm cu m/mol at 25 °C (est)

pKa = 2.23 (conjugate acid)

Congealing point: 23.8 °C, 24 °C|It has lowest molar absorptivity of all sunscreens and does not absorb throughout the near-ultraviolet range|Hydroxyl radical reaction rate constant: 3.48X10-11 cu cm/molecule-sec at 25 °C (est)

This compound is sensitive to air and light. Slightly water soluble (NTP, 1992).

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

An aromatic amine and ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

NONH for all modes of transport

1

R36/37/38

S26-S37/39

CB3325000

Xi

Stable. Combustible. Incompatible with strong oxidizing agents.

P261-P305 + P351 + P338

H315-H319-H335

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.|Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Synthetic flavoring substances and adjuvants /for animal drugs, feeds, and related products/ that are generally recognized as safe for their intended use, within the meaning of section 409 of the Act. Methyl anthranilate is included on this list.|Synthetic flavoring substances and adjuvants /for human consumption/ that are generally recognized as safe for their intended use, withn the meaning of section 409 of the Act. Methyl anthranilate is included on this list.|Sunscreen active ingredients. The active ingredient of the product consists of any of the following, within the concentration specified for each ingredient, and the finished product provides a minimum SPF value of not less than 2 as measured by the testing procedures established in subpart D of this part: ... (h) Methyl anthranilate up to 5 percent.

This chemical is combustible. (NTP, 1992)

|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 2546 companies from 12 notifications to the ECHA C&L Inventory.|H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)|Eye/face protection: Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU).|Skin protection: Handle with gloves.|Body Protection: Impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Combustible liquid.

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.|Water or foam may cause frothing. /Use/ alcohol foam.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.|ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Environmental precautions: Do not let product enter drains.|Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.|Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

A skin irritant.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

SOURCE DOMINATED: Methyl anthranilate was detected not quantified in ambient air samples from the Thane Belapur Industrial area of Mumbai, India; sampling was conducted during summer, monsoon and winter seasons, 2004(1).

Methyl anthanilate is a component in tobacco(1).

IDENTIFICATION AND USE: Methyl anthranilate can occur a colorless to pale-yellow liquid, or crystals with bluish fluorescence. It is used as a non-toxic and non-lethal bird repellent. It is used also in flavorings and perfumes. Although methyl anthranilate was not 100% effective in preventing honey bee stinging, it seemed to reduce number of stings below the average human LD50, indicative of a promising tool for preventing honey bee venom toxicity and wasp colonization. HUMAN STUDIES: Maximization tests were carried out on groups of 24 and 26 volunteers. The material was tested at a 10% concentration in petrolatum and produced no sensitization reactions. It produced no irritation after a 48 hr closed-patch test on human subjects and this result was confirmed when the test was repeated. ANIMAL STUDIES: Methyl anthranilate applied full strength to intact or abraded rabbit skin for 24 hr under occlusion was moderately irritating. Groups of 10 male and 10 female weanling rats were maintained for a period of 115 days on diets containing methyl anthranilate at levels of 0, 3,000 and 10,000 ppm. The only observable effects noted at the 10,000 ppm level were increases in the average weights of the liver and kidneys, and slight (minimal) histological changes in the kidneys. There was no increase in the incidence of primary lung tumors in mice over a period of 24 weeks, that received a total dose of methyl anthranilate of 2.25 or 11.2 g/kg bw (repeated ip injections three times a week for a total of 24 injections). Methyl anthranilate was found to be negative when tested for mutagenicity using the Salmonella/ microsome preincubation assay, Methyl anthranilate was tested in as many as 5 Salmonella typhimurium strains (TA1535, TA1537, TA97, TA98, and TA100) in the presence and absence of metabolic activation. ECOTOXICITY STUDIES: No treatment-related mortality of catfish was observed. Handling times of catfish fingerlings captured by herons from tubs treated with methyl anthranilate-based bird repellent increased at application rates of 19.6 kg/ha or greater.

LD50 Guinea pig oral 2780 mg/kg|LD50 Mouse oral 3900 mg/kg|LD50 Rat oral 2910 mg/kg|LD50 Rabbit dermal 5,000 mg/kg bw

/AQUATIC SPECIES/ ...The acute toxicity of methyl anthranilate /was tested/ in a static system against the fry of four species of fish. The LC50 at 24 hr for Atlantic salmon (Salmo salar L.) was 32.3 mg/L, with the no observable effect limit at 6 mg/L.|/AQUATIC SPECIES/ ...The methyl anthranilate-based bird repellent, ReJeX-iT TP-40TM (TP-40), /was evaluated/ for 1) its toxicity to channel catfish fingerlings (catfish), Ictalurus punctatus; 2) its effect on great blue heron (heron), Ardea herodias feeding behavior; 3) its efficacy in reducing heron predation on catfish; and 4) its effects on catfish growth. TP-40 effectively maintained MA /methyl anthranilate/ concentrations near the water's surface and below toxic levels for catfish in the water column. Water samples collected from 0.03 and 0.35 m below the surface of catfish rearing tanks (6,664 L) treated at application rates up to the equivalent of 200 kg/ha contained less than 5 ppm active ingredient, which is less than the no observable effect limit for catfish fry. No treatment-related mortality of catfish was observed. Handling times of catfish fingerlings captured by herons from tubs treated with TP-40 initially increased at application rates of 19.6 kg/ha or greater.

Methyl anthranilate is reported found in several essential oils: neroli, orange, bergamont, lemon, mandarin, jasmine, tuberose, gardenia, champaca, ylang-ylang and grape. It is also reported found in the juice and oil of Citris labrusca, peel oil of orange, bitter orange and tangerine, grapes, strawberry, cocoa, starfruit, tea, red and white wine, rice bran and babco fruit (Carica pentagona Heilborn)(1).

Methyl anthranilate's production and use as a flavor additive(1,2) may result in its release to the environment through various waste streams. Its use as a perfume(1,2) and bird repellant(3) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 75(SRC), determined from a log Kow of 1.88(2) and a regression-derived equation(3), indicates that methyl anthranilate is expected to have high mobility in soil(SRC). However, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(4,5), suggesting that mobility may be much lower in some soils(SRC). Volatilization of methyl anthranilate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.9X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 2.7X10-2 mm Hg(6), and water solubility, 2,850 mg/L(7). Methyl anthranilate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(6). Utilizing a soil biodegradation screening test, 100% biodegradation in 64 days of analogous 2-aminobenzoic acid(8) indicates that biodegradation of methyl anthranilate may be an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 75(SRC), determined from a log Kow of 1.88(2) and a regression-derived equation(3), indicates that methyl anthranilate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 1.9X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 2.7X10-2 mm Hg(5), and water solubility, 2,850 mg/L(6). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 24 and 180 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 8(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Methyl anthranilate, present at 50 mg/L, exhibited 100% biodegradation in 20 days when incubated in dechlorinated, charcoal-filtered water(8) indicating that biodegradation of methyl anthranilate may be an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl anthranilate, which has a vapor pressure of 2.7X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyl anthranilate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hrs(SRC), calculated from its rate constant of 3.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Methyl anthranilate contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of methyl anthranilate with photochemically-produced hydroxyl radicals has been estimated as 3.5X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 11 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Methyl anthranilite was not subject to hydrolysis at 25 °C in phosphate buffer media at pH 5, 7 and 9(2). A base-catalyzed second-order hydrolysis rate constant of 4.0X10-2 L/mole-sec(SRC) was estimated using a structure estimation method(1); this corresponds to half-lives of 5.5 yrs and 200 days at pH values of 7 and 8, respectively(1). Hydrolysis losses of 0-4, 3-7 and 3-9% at pH 5, 7 and 9, respectively, after 38 days in a buffered solution were reported(2). Methyl anthranilate contains chromophores that absorb at wavelengths >290 nm(2) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). The compound slowly photodegraded under simulated UV light with 44% lost after exposure to the equivalent of approximately 1200 hrs of natural sunlight(2).

An estimated BCF of 8 was calculated for methyl anthranilate(SRC), using a log Kow of 1.88(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low (SRC).

The Koc of methyl anthranilate is estimated as 75(SRC), using a log Kow of 1.88(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that methyl anthranilate is expected to have high mobility in soil(SRC). However, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(4,5), suggesting that mobility may be much lower in some soils(SRC).

The Henry's Law constant for methyl anthranilate is estimated as 1.9X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 0.027 mm Hg(1), and water solubility, 2,850 mg/L(2). This Henry's Law constant indicates that methyl anthranilate is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 24 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 180 days(SRC). Methyl anthranilate's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Methyl anthranilate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

According to the 2016 TSCA Inventory Update Reporting data, 4 reporting facilities estimate the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of methyl anthraniliate in the United States may be as low as 10 or as high as 50 per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 104,513 workers (49,243 of these are female) are potentially exposed to methyl anthranilate in the US(1). Occupational exposure to methyl anthranilate may occur through inhalation and dermal contact with this compound at workplaces where methyl anthranilate is produced or used(SRC). The general population may be exposed to methyl anthranilate via ingestion of food, using tobacco and dermal contact with consumer products containing methyl anthranilate(SRC).

/EXPL THER/ Human victims of a massive number of stings have been steadily increasing since the invasion of Africanized honey bees (Apis mellifera) to the United States in 1990. Multiple honey bee stings may result in venom toxicity, leading to renal failure and even death. Here we tested the efficacy of methyl anthranilate as a honey bee repellent during a massive defensive response by Africanized honey bees. An aerosolized solution of 10% methyl anthranilate reduced the number of defensive bee hits to a retreating victim by 95% compared with a water control. One hundred fifty milliliters of the 10% methyl anthranilate solution sprayed onto stationary foam balls covered with black suede leather located 2 m from provoked Africanized colonies received 80% fewer stings than targets treated with water. Methyl anthranilate (100%) delivered through a UV blocking 3 mil polyethylene pouch was 100% effective in preventing Polistes colonization in wildlife observation huts and from the roof overhang of home patios. Although methyl anthranilate was not 100% effective in preventing honey bee stinging, it seemed to reduce number of stings below the average human LD50, indicative of a promising tool for preventing honey bee venom toxicity and wasp colonization.

Substantial evidence has accumulated showing that many esters readily undergo enzymatic hydrolysis into their component alcohols and acids. In the case of methyl anthranilate, there is direct experimental evidence showing that this ester, while only slowly hydrolyzed by artificial gastric or pancreatic juice, was readily hydrolyzed in rat liver homogenate (50% in 26.6 minutes) and rapidly hydrolyzed in a homogenate of rat small intestine mucosa (50% in 2.5 minutes). Methyl anthranilate has also been shown to be completely hydrolyzed (>99% in two hours) in pig liver homogenate; but was more resistant to hydrolysis in pig jejunum homogenate and completely unhydrolysed by a pancreatin preparation. The hydrolysis products of methyl anthranilate are, of course, methyl alcohol and anthranilic acid. Methyl alcohol is readily metabolized via well-known pathways to carbon dioxide and water. Anthranilic acid is a normal metabolite in man and is excreted in the urine, primarily, as o-aminohippuric acid and to a lesser extent as anthranilic acid glucuronide.

SYMPTOMS: This compound is an irritant to the skin. ACUTE/CHRONIC HAZARDS: This compound may cause irritation on contact. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Immediate First Aid: Ensure that adequate decontamination has been carried out. if patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket musk, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. if vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

/HUMAN EXPOSURE STUDIES/ Maximization tests were carried out on groups of 24 and 26 volunteers. The material was tested at a 10% concentrationin petrolatum and produced no sensitization reactions.|/HUMAN EXPOSURE STUDIES/ Tested at 10% in petrolatum, it produced no irritation after a 48 hr closed-patch test on human subjects and this result was confirmed when the test was repeated.

methyl anthranilate

Grade: Technical, FCC.|Rejex-it TP-40 (Avian Enterprises Limited LLC): Active ingredient: methyl anthranilate 40.0%.|Rejex-it MA (Avian Enterprises Limited LLC): Active ingredient: methyl anthranilate 98.5%.|Rejex-it AG-36 (Avian Enterprises Limited LLC): Active ingredient: methyl anthranilate 14.5%.|For more Formulations/Preparations (Complete) data for Methyl anthranilate (13 total), please visit the HSDB record page.

Food, beverage, and tobacco product manufacturing|Benzoic acid, 2-amino-, methyl ester: ACTIVE|/Because it does not absorb UV radiation & has low molar absorptivity it is used as a sunscreen and ...in combination with other sunscreens or light-protectives. ... Dose: 5% in creams, lotions or ointments.

Method: AOAC 950.25, Methyl Anthranilate in Non-alcoholic Beverages, Colorimetric Method; Analyte: methyl anthranilate; Matrix: beverages containing <500 mg/l; Detection Level: not provided.|Method: AOAC 950.26, Methyl Anthranilate in Non-alcoholic Beverages, Gravimetric Method; Analyte: methyl anthranilate; Matrix: beverages containing greater than or equal to 500 mg/l; Detection Level: not provided.|A method for the simultaneous determination of 5-(hydroxymethyl)-2-furaldehyde and methyl anthranilate in honey is reported. The analysis is carried out by reversed-phase gradient-elution high performance liquid chromatography (HPLC). The proposed method can be applied for both the routine characterization of honey based on the methyl anthranilate content and the quality control analysis based on the 5-(hydroxymethyl)-2-furaldehyde level.|Methyl anthranilate fortified blueberries were extracted with methanol, cleaned up by solid phase extraction and analyzed by reverse phase high performance liquid chromatography, Methyl anthranilate was quantified by UV absorbance and fluorescence detection. Recoveries of 13% and 14% were obtained for blueberry samples fortified with methyl anthranilate at 5 and 0.15 ppm respectively. The method limits of detection for ultraviolet and fluorescence detection were 0.04 and 0.009 ug methyl anthranilate/g, respectively.

Food additives -> Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT; -> JECFA Functional Classes|Flavoring Agents -> JECFA Flavorings Index|Cosmetics -> Masking

Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT;