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Deferoxamine mesylate

Deferoxamine mesylate structure

CAS No:
138-14-7
Formula:
C25H48N6O8.CH4O3S
Chemical Name:
Deferoxamine mesylate
Synonyms:
Butanediamide,N4-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxy-,methanesulfonate (1:1);Propionohydroxamic acid,N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-,monomethanesulfonate (salt);Butanediamide,N′-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-,monomethanesulfonate (salt);Propionohydroxamic acid,N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-,methanesulfonate;Desferrioxamine methanesulfonate;Desferrioxamine B mesylate;Desferrioxamine B methanesulfonate;Deferoxamine B mesylate;Deferrioxamine methanesulfonate;Desferrioxamine mesylate;Desferal mesylate;Desferal;Deferrioxamine B methanesulfonate;Deferoxamine mesylate;Deferoxamine methanesulfonate;DFOM;Ba 33112;NSC 644468;DFX mesylate;Desferrioxamine mesilate;17688-38-9;35908-62-4
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

Description

Deferoxamine mesylate is an iron chelator that binds free iron in a stable complex, preventing it from engaging in chemical reactions.

Deferoxamine is a parenterally administered iron chelating agent used to treat transfusion related chronic iron overload. Deferoxamine rarely causes serum aminotransferase elevations during therapy and has not been convincingly linked to instances of clinically apparent liver injury.|Deferoxamine Mesylate is the mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and ferrioxamine, a water-soluble complex excreted by the kidneys and in the feces via the bile. This agent does not readily chelate iron bound to transferrin, hemoglobin, myoglobin or cytochrome.|Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.

Deferoxamine mesylate Basic Attributes

Molecular Weight：

656.79

Exact Mass：

752.329590

EC Number：

205-314-3

UNII：

V9TKO7EO6K

NSC Number：

756718|644468

DSSTox ID：

DTXSID6037649

NCI Thesaurus Code：

C417

Characteristics

PSA：

269

Appearance：

white to off-white powder

Melting Point：

148-149 °C

Boiling Point：

1061.9°C at 760 mmHg

Flash Point：

538.5ºC

Water Solubility：

H2O: 50 mg/mL

Storage Conditions：

−20°C

Collision Cross Section：

221.4 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

UG5310000

Stability/Shelf Life：

RECONSTITUTED SOLN ARE STABLE FOR 2 WK @ ROOM TEMP /MESYLATE/

Precautionary statement(s)：

P201, P202, P261, P264, P271, P272, P280, P281, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P308+P313, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Danger|H315 (80%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P261, P264, P271, P272, P280, P281, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P308+P313, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 9 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Hepatotoxicity：

In large clinical trials, elevations in serum aminotransferase levels were rare in patients receiving deferoxamine and instances of acute, clinically apparent liver injury were not reported. Patients with transfusion related iron overload often have concurrent chronic hepatitis B or C, and elevations of serum aminotransferase levels during chelation therapy may be due to natural fluctuations in the underlying chronic liver disease activity. Nevertheless, elevations in serum aminotransferase levels and “hepatic dysfunction” are listed as potential adverse events in product labels for deferoxamine. After an early report of hepatitis occurring in patient on hemodialysis receiving deferoxamine to reduce aluminum levels, there have been no further published instances of clinically apparent liver injury that have been convincingly linked to deferoxamine therapy.

Drug Information

LiverTox Summary：

Drug Classes：

Hematological Agents

MeSH：

Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994) (See all compounds classified as Siderophores.)

MeSH Entry Terms：

Deferoxamine

Deferoxamine mesylate Use and Manufacturing

Uses

chelating agent (Fe & Al)

Use Classification：

Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:656.8
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:23
Exact Mass:656.34147767
Monoisotopic Mass:656.34147767
Topological Polar Surface Area:269
Heavy Atom Count:44
Complexity:832
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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Ingredients	The main ingredient of this product is deferoxamine mesylate.
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Registered Holders

EXCELLA GMBH AND CO KG

United States
Active
Excella GmbH & Co. KG

Germany
Active
TEVA PHARMACEUTICAL INDUSTRIES LTD

France
Active

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Recommended Suppliers of Deferoxamine mesylate

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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Deferoxamine mesylate

CAS No.: 138-14-7

Content: 99.00%

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Dayang Chem (Hangzhou) Co.,Ltd Contact Supplier

CN
3 YRS

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deferoxamine mesilate CAS NO.138-14-7

CAS No.: 138-14-7

Grade: Industrial Grade

Content: 98%

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