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Home > Encyclopedia > N,N′-Dinitrosopiperazine

N,N′-Dinitrosopiperazine

N,N′-Dinitrosopiperazine structure

N,N′-Dinitrosopiperazine 

structure
  • CAS No:

    140-79-4

  • Formula:

    C4H8N4O2

  • Chemical Name:

    N,N′-Dinitrosopiperazine

  • Synonyms:

    Piperazine,1,4-dinitroso-;1,4-Dinitrosopiperazine;N,N′-Dinitrosopiperazine;DNP;NSC 339

Description

Pale Yellow Solid

N,N′-Dinitrosopiperazine Basic Attributes

144.13

144.13

205-434-6

GU48C6581I

339

DTXSID0020527

PALE YELLOW PLATES FROM WATER

2933599090

Characteristics

65.34000

-0.88

1.4165 (rough estimate)

158 °C

262.72°C (rough estimate)

199.4±26.8 °C

1.8500 (estimate)

SLIGHTLY SOL IN WATER, ACETONE; VERY SOL IN HOT ALCOHOL

Safety Information

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. (See all compounds classified as Carcinogens.)

AFTER IP ADMIN OF 10 MG/69.5 MUCI PER KG (2,5-(14)C)-N,N'-DINITROSOPIPERAZINE TO RATS 1% OF RADIOACTIVITY WAS EXHALED AS (14)CO2, 1% WAS EXCRETED VIA BILE & ABOUT 40% WAS EXCRETED IN URINE.

AFTER ADMIN OF (2,5-(14)C)-DINITROSOPIPERAZINE TO RATS TWO OF THE URINE METABOLITES WERE IDENTIFIED AS 3-HYDROXYNITROSOPYRROLIDINE & 1-NITROSOPIPERAZINONE-(3).

1,4-dinitrosopiperazine

N,N′-Dinitrosopiperazine Use and Manufacturing

Methods of Manufacturing

REACTION OF PIPERAZINE WITH NITRITE

Uses

N,N'-Dinitrosopiperazine (DNP) induces nasopharyngeal carcinoma (NPC) and shows organ specificity to the nasopharyneal epithelium.

Production

(1977) NOT PRODUCED COMMERCIALLY IN US|(1979) NOT PRODUCED COMMERCIALLY IN US

ESSENTIALLY 100% AS A RESEARCH CHEMICAL

Piperazine, 1,4-dinitroso-: ACTIVE

N,N'-DINITROSOPIPERAZINE & N-NITROSOPIPERAZINE WERE SEPARATED & DETERMINED BY HIGH-PRESSURE LIQUID CHROMATOGRAPHY.|THIN-LAYER CHROMATOGRAPHY PROCEDURE FOR SEPARATION OF PIPERAZINE & ITS N-NITROSO & N,N'-DINITROSO DERIVATIVES ON SILICA GEL ADSORBENT IS REPORTED.

Computed Properties

Molecular Weight:144.13
XLogP3:-0.8
Hydrogen Bond Acceptor Count:6
Exact Mass:144.06472551
Monoisotopic Mass:144.06472551
Topological Polar Surface Area:65.3
Heavy Atom Count:10
Complexity:115
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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