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Pirenoxine

Pirenoxine structure

CAS No:
1043-21-6
Formula:
C16H8N2O5
Chemical Name:
Pirenoxine
Synonyms:
5H-Pyrido[3,2-a]phenoxazine-3-carboxylic acid,1-hydroxy-5-oxo-;1-Hydroxy-5-oxo-5H-pyrido[3,2-a]phenoxazine-3-carboxylic acid;1-Hydroxy-3-carboxy-5H-pyrido[3,2-a]phenoxazin-5-one;1-Hydroxy-5H-pyrido[3,2-a]phenoxazin-5-one-3-carboxylic acid;Catalin;Catalin (pharmaceutical);Clarvisan;HPPC;Pirenoxine;Catalin K;Kary-Uni;Pyrphenoxone;Pirfenoxone;1,5-Dioxo-4H-pyrido[3,2-a]phenoxazine-3-carboxylic acid;9007-24-3
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

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Description

Pirenoxine is an organic molecular entity.

Pirenoxine Basic Attributes

Molecular Weight：

308.25

Exact Mass：

308.25

EC Number：

213-872-4

UNII：

27L0EP6IZK

DSSTox ID：

DTXSID6048335

Characteristics

PSA：

105

XLogP3：

2.24480

Density：

1.7g/cm3

Melting Point：

247 °C (decomp)

Boiling Point：

515.8ºC at 760mmHg

Flash Point：

265.7ºC

Refractive Index：

1.793

Vapor Pressure：

1.83E-11mmHg at 25°C

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

1-hydroxy-5H-pyrido-(3,2-a)-phenoxazin-5-one-3-carboxylic acid

Pirenoxine Use and Manufacturing

antiviral

Computed Properties

Molecular Weight:308.24
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:308.04332136
Monoisotopic Mass:308.04332136
Topological Polar Surface Area:105
Heavy Atom Count:23
Complexity:771
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Hydroquinone

Dimethyl sulfate

Drug Function and Efficacy

According to the quinone theory, pyrenoxine can competitively hinder the binding of quinone compounds to lens water-soluble proteins, thereby preventing the denaturation of lens proteins.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pirenoxine eye drops
Ingredients	Kalin-U eye drops are orange-yellow water-soluble suspensions, containing 0.05 mg of pyrenoxine per 1 ml. The additives include sodium edetate, benzalkonium chloride, concentrated glycerin and polysorbate 80.
Indication	Not yet clear
Specifications	0.005%(5ml:0.25mg)
Manufacturer	Ebe Pharmaceutical Co., Ltd.

Pirenoxine eye drops
Specifications	5ml:0.25mg

Pirenoxine
Specifications	－－－－
Manufacturer	Wuhan Wuyao Pharmaceutical Co., Ltd.

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Registered Holders

Wuhan Wuyao Pharmaceutical Co., Ltd.

China
Active

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