 Home > Encyclopedia > Meclizine hydrochloride

Meclizine hydrochloride

Meclizine hydrochloride structure

CAS No:
1104-22-9
Formula:
C25H27ClN2.2ClH
Chemical Name:
Meclizine hydrochloride
Synonyms:
Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-,hydrochloride (1:2);Piperazine,1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-,dihydrochloride;Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-,dihydrochloride;Ancolan dihydrochloride;Meclizine dihydrochloride;Parachloramine dihydrochloride;Postafene dihydrochloride;Meclozine hydrochloride;Postafen;Diadril;Meclozine dihydrochloride;Bonamine;Meclizine hydrochloride;1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazine dihydrochloride;Navidoxine;NSC 28728;1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride;1-[(4-Chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine dihydrochloride;Zentrip;1639-65-2
Categories:
Active Pharmaceutical Ingredients > Antiallergic Drugs

Description

Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sicknessTarget: Histamine H1 ReceptorMeclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, possesses anticholinergic, central nervous system depressant, and local anesthetic effects [1]. Meclizine is an agonist ligand for mouse CAR (constitutive androstane receptor), and an inverse agonist for human CAR. Meclizine increases mCAR transactivation in a dose-dependent manner, s

A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

Meclizine hydrochloride Basic Attributes

Molecular Weight：

463.87

Exact Mass：

462.139618

EC Number：

214-164-8

DSSTox ID：

DTXSID9045348

HScode：

2933499090

Characteristics

PSA：

6.48000

XLogP3：

7.03540

Appearance：

white to beige

Density：

1.159g/cm3

Melting Point：

215 °C

Boiling Point：

495.3ºC at 760mmHg

Flash Point：

253.3ºC

Water Solubility：

DMSO: soluble 5mg/mL, clear (warmed)

Storage Conditions：

2-8°C

Vapor Pressure：

6E-10mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-63

safety instructions：

22-36

RTECS Number：

TL2005000

Marks：

Precautionary statement(s)：

P280-P301 + P312 + P330

Hazard Statements：

H302-H361

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 43 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)|Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)|Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

MeSH Entry Terms：

Agyrax

Meclizine hydrochloride Use and Manufacturing

Uses

cholinergic, diagnostic aid Meclizine hydrochloride is an antagonist of histamine receptors, which can resist the antihypertensive effect caused by histamine and protect the death of animals caused by lethal histamine. It has central inhibitory and local anesthetic effects. Indications: Treatment and prevention of nausea, vomiting and dizziness caused by motion sickness.

Manufacturing Info：

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, hydrochloride (1:2): INACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:463.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:462.139632
Monoisotopic Mass:462.139632
Topological Polar Surface Area:6.5
Heavy Atom Count:30
Complexity:448
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Meclizine Hydrochloride

Registered Holders

THINQ PHARMA-CRO LTD

United States
Active
Sri Krishna Pharmaceuticals Ltd

United States
Active
JUBILANT PHARMOVA LTD

United States
Active

See More Registered Holders

Recommended Suppliers of Meclizine hydrochloride

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Meclizine dihydrochloride

CAS No.: 1104-22-9

Content: 99.00%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high purity hot sale Meclizine dihydrochloride 99% high quality see COA KANBEI

CAS No.: 1104-22-9

Grade: Industrial Grade

Content: 99%

Inquiry