2-Methoxy-5-nitrobenzenediazonium

Method 1: 2, 4-Dinitroanisole is partially reduced. This method is mostly used in China, but most use 2, 4-dinitrochlorobenzene as raw material, firstly react with methanol to prepare 2, 4-dinitroanisole, and then perform partial reduction, using sodium disulfide as reducing agent. . Add 900kg of molten 2, 4-dinitrochlorobenzene and 1800L of methanol into the reaction pot, heat it to 40℃, add 579kg of 30% sodium hydroxide solution in 4h quickly and slowly, and control the temperature to 58-60℃ . Phenolphthalein test paper should be orange-red. Sampling and determining alkali content ≤0.1%, phenol content ≤0.6%, and product melting point ≥91.5℃, the reaction can be regarded as complete. The yield is about 95%. Cool the above reactants to 30°C, and add 2000L of 18% sodium disulfide solution quickly and slowly within 4h, and the temperature gradually rises to about 50°C. After adding the sodium disulfide, continue to keep the temperature at 50-55°C for 30 minutes. Sampling and testing reduction product melting point ≥116℃, content ≥97%, it is qualified. Cool the material to 20°C, filter, wash, and blow dry to obtain a crude product. The yield is about 76%. Add 1800L of clear water and the above crude product to the salt-forming tank, stir for 15min, then add 505L of 30% hydrochloric acid, heat to 85-90℃, stir for 2h, after the material is completely dissolved, add 3kg of activated carbon and clay, then stir for 30min, and let stand Separate the layers, aspirate the supernatant liquid and put it into the salting-out bucket. Under stirring, add 18% of the volume of salt at 65-70°C for salting-out. Naturally cool to 40°C, filter, and wash 3 times with saturated brine. The yield is about 97%. Method 2: Using o-anisidine as raw material, it is prepared after nitration. . Add 750L of water and 780kg of 40% nitric acid to the reaction kettle, slowly add 560kg of anthranil at 35-40°C with stirring, continue to stir and cool to 15-20°C after the addition, and vacuum filter for dehydration. When each 100kg anthranil nitrate sample is dried on a water bath, the weight loss should not exceed 4%. Add 1700kg of 95% sulfuric acid to the reaction pot, cool to 0-5°C, add 830kg of the above wet anthranil nitrate (equivalent to 800kg of dry anthranil nitrate) within 12 hours under stirring. After adding, continue to stir for 2h. Then dilute with 250L of water at 5-15℃, and add 1220L of sodium chloride solution with relative density of 1.169 at 10-20℃. Stir for 1h. Take the clear liquid to measure the relative density should be 1.38, the solution is clear, you can vacuum filter, the filter cake is washed twice with saturated salt solution, drained, and the finished product is obtained after drying. Method 3: The by-product 4-nitroanthranil in the production of red base B (C.I.37125) is recovered by 1, 5-naphthalenedisulfonic acid treatment.

It is mainly used as a developer for dyeing and printing cotton and viscose fabrics (preferably red and rose), and can be used as an intermediate for dyes and organic pigments.

Molecular Weight:180.14
XLogP3:2.8
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:180.04091606
Monoisotopic Mass:180.04091606
Topological Polar Surface Area:83.2
Heavy Atom Count:13
Formal Charge:1
Complexity:241
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes