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Phoxim

Phoxim structure

CAS No:
14816-18-3
Formula:
C12H15N2O3PS
Chemical Name:
Phoxim
Synonyms:
Phosphorothioic acid,O-[(cyanophenylmethylene)azanyl] O,O-diethyl ester;Glyoxylonitrile,phenyl-,oxime O,O-diethyl phosphorothioate;3,5-Dioxa-6-aza-4-phosphaoct-6-ene-8-nitrile,4-ethoxy-7-phenyl-,4-sulfide;Phosphorothioic acid,O,O-diethyl ester,O-[(α-cyanobenzylidene)amino] deriv.;BAY 77488;Bayer 77488;Phenylglyoxylonitrile oxime O,O-diethyl phosphorothioate;B 77488;Phoxim;Baythion;Benzoyl cyanide O-(diethoxyphosphinothioyl)oxime;Valexon;Volaton;BAY 5621;Bayer 5621;O,O-Diethyl O-(α-cyanobenzylideneamino) phosphorothioate;Folaton;Volaton bjdse 20;Tomiguard PE 50;Basileum SI;Basileum SI 84EC;Xylasan VL;Basileum SI 84;Sebacil;Toyothion;Jiubaojing;29556-99-8;35915-13-0;1195303-43-5
Categories:
Agrochemicals > Insecticides

Description

yellowish oily liquid, Specific gravity: 1.176 (20°C)

Phoxim is a synthetic organophosphate acetylcholinesterase inhibitor that is used as a pesticide. It is characterized as a yellow liquid, and exposure occurs by inhalation, ingestion, or contact.

Phoxim Basic Attributes

Molecular Weight：

298.3

Exact Mass：

298.30

EC Number：

238-887-3

UNII：

6F5V775VPO

DSSTox ID：

DTXSID8034324

NCI Thesaurus Code：

C80605

HScode：

29269090

Characteristics

PSA：

105.74000

XLogP3：

4.39

Density：

1.76 g/cm³ @ Temp: 20 °C

Melting Point：

6.1 °C

Boiling Point：

102 °C

Flash Point：

173.0±23.2 °C

Refractive Index：

nD20 1.5405

Water Solubility：

1.79e-05 M

Storage Conditions：

0-6°C

Vapor Pressure：

2.1×10 -3 Pa (20 °C)

Toxicity：

Oral-rat LD50; 300 mg/kg; Oral-Mouse LD50: 1050 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides, phosphorus oxides, sulfur oxides, cyanide fumes

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2810

wgk germany：

hazard class code：

22-50/53-62-43

safety instructions：

36-60-61-46-36/37

RTECS Number：

MD4740000

Marks：

Xn;N,N,Xn

Storage features：

Ventilated, low temperature and dry

Precautionary statement(s)：

P201-P260-P273-P280-P304 + P340 + P310-P403 + P233

Hazard Statements：

H302-H311-H317-H330-H361f-H410

GHS Classification：

|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P272, P273, P280, P281, P301+P312, P302+P352, P308+P313, P321, P330, P333+P313, P363, P391, P405, and P501|Danger|H301 (12.5%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P272, P273, P280, P281, P284, P301+P310, P301+P312, P302+P352, P304+P340, P308+P313, P310, P312, P320, P321, P322, P330, P333+P313, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 264 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Bioconcentration：

812.83

Drug Information

MeSH：

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)|Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)

Biological Half-Life：

6.92 Days

MeSH Entry Terms：

Bay 77488

Phoxim Use and Manufacturing

Methods of Manufacturing

The phoxim synthesis reaction is carried out in a solvent such as acetone, which is slightly slower in the aqueous solution. In industrial production, the sodium 2-oximinobenzeneacetonitrile is 10% excess, and the reaction temperature is about 40°C. Tianjin Pesticide Plant has studied the catalytic synthesis method using water as the solvent, the catalyst used is triethylamine, the operation process: 373g of 0.55mol content of 25% 2-oxime benzene acetonitrile sodium solution in water, adding 0.5mol dropwise within 30min at room temperature 105% O, O-diethyl thiophosphoryl chloride 105g, drop, then add a little catalyst triethylamine, stir for 30min, warm up to 45 ~ 50 ℃, react for 1.5h, wash, separate, dry 156 to 161g of product was obtained, with a content of 87% to 92% and a yield of 94% to 96%. The intermediate 2-oxime phenylacetonitrile sodium is prepared by the action of phenylacetonitrile and ethyl nitrite. The catalyst is alkaline substance such as sodium alkoxide + NaOH, lye. If liquid alkali is used as the catalyst, the reaction temperature is 35-40°C.

Uses

Insecticide.

Use Classification：

Agrochemicals -> Insecticides|INSECTICIDES

Computed Properties

Molecular Weight:298.30
XLogP3:4.4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:298.05410052
Monoisotopic Mass:298.05410052
Topological Polar Surface Area:95.9
Heavy Atom Count:19
Complexity:389
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

2-Methoxyethanol

Triethylamine

Ethanol

Sodium nitrite

Sulfuric acid

Recommended Suppliers of Phoxim

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

High Quality 99% Purity of Phoxim CAS NO 14816-18-3 ISO 9001:2005 REACH Verified Producer

CAS No.: 14816-18-3

Grade: Industrial Grade

Content: 99%

Inquiry
Shanghai Lonwin Chemical Co.,Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of CHEMICALS,REAGENTS

High quality Phoxim CAS NO.14816-18-3

CAS No.: 14816-18-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Weiyel Inc Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of reference material,reference standards,Reference Standard Materials,ICP & ICP-MS Single/Mix Standards,Analytical standards,Lab reagents,Lab Chemicals,Fine chemicals,Bioreagents

Phoxim in Methanol

CAS No.: 14816-18-3

Content: 1000%

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