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Cefatrizine

Cefatrizine structure

CAS No:
51627-14-6
Formula:
C18H18N6O5S2
Chemical Name:
Cefatrizine
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-5-ylthio)methyl]-,(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[amino(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-4-ylthio)methyl]-,[6R-[6α,7β(R*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-4-ylthio)methyl]-,(6R,7R)-;1H-1,2,3-Triazole,5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid deriv.;(6R,7R)-7-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-5-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;BL-S 640;Cefatrizine;SKF 60771;Antibiotic BL-S 640;S 640P;Cephatrizin;7-[D-α-Amino-α-(4-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid;Cephatrizine;Cepticol;Cefaperos;118191-02-9;55818-58-1
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

ChEBI: A cephalosporin compound having (1H-1,2,3-triazol-4-ylsulfanyl)methyl and [(2R)-2-amino-2-(4-hydroxyphenyl)]acetamido side-groups. An antibacterial drug first prepared in the 1970s, it has more recently been found to be n inhibitor of eukaryotic elongation factor-2 kinase (eEF2K), which is known to regulate apoptosis, autophagy and ER stress in many types of human cancers.

Cefatrizine Basic Attributes

Molecular Weight：

462.51

Exact Mass：

462.50

EC Number：

257-324-2

Characteristics

PSA：

225

XLogP3：

-0.41

Appearance：

White to slightly yellowish powder

Density：

1.7±0.1 g/cm3

Boiling Point：

948.1±65.0 °C at 760 mmHg

Flash Point：

527.2±34.3 °C

Refractive Index：

1.794

Toxicity：

Oral-rat LD: > 6000 mg/kg; Abdominal cavity-mouse LD50: 6410 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

Toxicity

Toxicity class：

moderately toxic

Cefatrizine Use and Manufacturing

Antidepressant, Selective serotonin reuptake inhibitor

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CAS No.: 51627-14-6

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Cefatrizine 51627-14-6

CAS No.: 51627-14-6

Grade: Pharmaceutical Grade

Content: 99%

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