Polyinosinic acid-polycytidylic acid s...
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Polyinosinic acid-polycytidylic acid s...
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CAS No:
42424-50-0
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Formula:
(C10H13N4O8P)x·(C9H14N3O8P)x
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Chemical Name:
Polyinosinic acid-polycytidylic acid s...
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CAS No:
Description
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis[1][2].
Polyinosinic acid-polycytidylic acid s... Use and Manufacturing
TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid (Poly(I) • Poly(C)) is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
Computed Properties
Molecular Weight:694.4
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:18
Rotatable Bond Count:8
Exact Mass:694.08872108
Monoisotopic Mass:694.08872108
Topological Polar Surface Area:351
Heavy Atom Count:45
Complexity:1090
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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