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Isoprinosine

Isoprinosine structure

CAS No:
36703-88-5
Formula:
C10H12N4O5.3C9H9NO3.3C5H13NO
Chemical Name:
Isoprinosine
Synonyms:
Inosine,compd. with 1-(dimethylamino)-2-propanol 4-(acetylamino)benzoate (1:3:3);Inosine,compd. with 1-(dimethylamino)-2-propanol 4-(acetylamino)benzoate (salt) (1:3);Benzoic acid,4-(acetylamino)-,compd. with 1-(dimethylamino)-2-propanol and inosine (3:3:1);2-Propanol,1-(dimethylamino)-,4-(acetylamino)benzoate (salt),compd. with inosine (3:1);Isoprinosine;Inosiplex;Isoprinosin;NPT 10381;Methisoprinol;Inosine pranobex;Inosine acedobene dimepranol;Delimmun;Aviral;Modimmunal;Pranosina;Pranosine;Viruxan;NP 113;Groprinosin;Metyzoprynol;Imunovir;Immunovir;36507-51-4;36595-05-8;39534-71-9
Categories:
Active Pharmaceutical Ingredients > Drugs Influencing Immune Function

Description

Inosine pranobex is a potent, broad-spectrum antiviral compound for HIV infection. Inosine pranobex is an immunopotentiator[1].

Inosine Pranobex is a formulation containing inosine, 4-acetamidobenzoic Acid, and N,N-dimethylaminoisopropanol, with immunomodulatory and antiviral activities. Although the exact mechanism of action is unknown, inosine pranobex appears to act as a thymus hormone analog; following administration, this agent may both induce T-cell differentiation and potentiate lymphoproliferative responses against transformed or virally-infected cells.|An alkylamino-alcohol complex of inosine used in the treatment of a variety of viral infections. Unlike other antiviral agents, it acts by modifying or stimulating cell-mediated immune processes rather than acting on the virus directly.

Isoprinosine Basic Attributes

Molecular Weight：

1115.23

Exact Mass：

1114.554688

EC Number：

253-162-1

UNII：

W1SO0V223F

NCI Thesaurus Code：

C601

ATC Code：

J - Antiinfectives for systemic use

Characteristics

PSA：

399

XLogP3：

1.76610

Boiling Point：

732.8°C at 760 mmHg

Flash Point：

397ºC

Toxicity：

LD50 in mice and rats (mg/kg): >4000 orally and i.p. (Gordon)

Drug Information

MeSH：

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)|Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

MeSH Entry Terms：

Imunovir

Isoprinosine Use and Manufacturing

The main pharmacological effects of isopinosine are as follows: (1) Isopinosine can promote the proliferation of lymphocytes induced by phytohemagglutinin (PHA), concanavalin A (ConA), tetanus toxoid and influenza virus. (2) Enhance the delayed type allergic reaction caused by dinitrochlorobenzene, and restore the delayed type allergic reaction suppressed by cyclophosphamide to normal. (3) Restore the proliferative response of mouse spleen lymphocytes to ConA, which is inhibited by cyclophosphamide. (4) This product can also promote the production of interleukin 1 (IL-1), interleukin 2 (IL-2) and interferon, and enhance the activity of mononuclear macrophages and natural killer cells (NK). This product can also restore normal immune function due to aging, including decreased lymphocyte proliferation caused by aging, NK cytotoxicity, monocyte chemotaxis, and the number of plaque-forming cells. Normal or close to normal.

Computed Properties

Molecular Weight:1115.2
Hydrogen Bond Donor Count:13
Hydrogen Bond Acceptor Count:22
Rotatable Bond Count:14
Exact Mass:1114.55464106
Monoisotopic Mass:1114.55464106
Topological Polar Surface Area:399
Heavy Atom Count:79
Complexity:658
Defined Atom Stereocenter Count:4
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:7
Compound Is Canonicalized:Yes

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