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Flavonoids

6-Demethoxytangeretin

(6601-66-7)
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase (ALK) and mitogen-activated protein kinase (MAPK) pathways[1]. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons[2].

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Reynoutrin

(549-32-6)
Reynoutrin (Quercetin-3-D-xyloside) is a flavonoid from Psidium cattleianum, with antioxidant and radical-scavenging activity[1].

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(-)-Vestitol

(35878-41-2)
ChEBI: A methoxyisoflavan that is (R)-isoflavan substituted by a methoxy group at position 4' and hydroxy groups at positions 7 and 2' respectively.

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Hesperetin 7-glucoside

(31712-49-9)
ChEBI: A flavanone 7-O-beta-D-glucoside having hesperetin as the flavanone component.

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Myricetin 3-O-galactoside

(15648-86-9)
ChEBI: A glycosyloxyflavone that is myricetin with a beta-L-galactosyl residue attached at position 3.

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epimedoside A

(39012-04-9)
Epimedoside A is a flavonoid isolated from the roots of Epimedium wushanense. Epimedoside A exhibits significant antioxidant activity in vitro[1].

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Kushenol A

(99217-63-7)
Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].

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Flavonoids, also known as bioflavonoids (bioflavonoids), are a type of compound that exists in nature and has a 2-phenyl flavonone structure. Widely distributed in the plant kingdom, it is a large class of important natural compounds. Flavonoids mostly have colors, and their different colors add more colors to the family of natural pigments.

Frequently Asked Questions

What are flavonoids and why are they important?

Flavonoids are a diverse group of phytonutrients found in almost all fruits and vegetables. They are known for their antioxidant, anti-inflammatory, and immune-supporting properties. Common subclasses include flavones, flavonols, flavanones, isoflavones, and anthocyanidins. Due to their health-promoting effects, flavonoids are widely used in dietary supplements, functional foods, and natural therapeutics.

What are the common natural sources of flavonoids?

Flavonoids occur naturally in a wide variety of plant-based foods and beverages. Rich sources include citrus fruits (flavanones), berries (anthocyanidins), onions and apples (flavonols), soybeans (isoflavones), and tea—especially green and black tea (catechins and theaflavins). Including a colorful diet with diverse fruits, vegetables, legumes, and herbs helps ensure adequate flavonoid intake.

What should buyers consider when sourcing high-quality flavonoid extracts?

When sourcing flavonoid extracts, buyers should evaluate:1. Purity and concentration levels (e.g., HPLC-certified assays).2. Botanical origin and extraction method (e.g., solvent-free or ethanol-based).3. Compliance with regulatory standards like ISO, GMP, or FDA GRAS status.4. Supplier transparency regarding heavy metals, pesticides, and microbial testing.5. Batch-to-batch consistency and documentation (Certificates of Analysis).These factors ensure safety, efficacy, and suitability for end-use applications.

Are there different types of flavonoid compounds used commercially?

Yes, several flavonoid compounds are commonly used in commercial products. Key examples include quercetin (a flavonol with strong antioxidant activity), hesperidin (a citrus flavanone supporting vascular health), epigallocatechin gallate (EGCG from green tea, known for metabolism support), genistein (a soy isoflavone used in hormonal health formulations), and rutin (used for capillary strength and anti-edema effects). Each type offers distinct biological activities and application benefits.

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