The Use Of Gas Chromatography In Pharmaceutical Industry

Chinese herbal medicine, as themain pharmaceutical chemical category, is a treasure of Chinese traditionalculture. In the process of disease treatment, Chinese herbal medicine has lessside effects and good disease treatment effect, and is highly concerned by thepublic. With the gradual popularity of returning to nature, Chinese herbalmedicine is developing rapidly, and Chinese herbal medicine has a gooddevelopment prospect. In order to ensure the planting yield of Chinese herbalmedicines, Chinese herbal medicines need to be sprayed with pesticides manytimes during planting, which will cause pesticide residues in Chinese herbalmedicines, which will have a serious impact on the human body. Therefore, it isof great practical significance to check the pesticide entanglement of Chineseherbal medicines and understand the practical value of Chinese herbalmedicines.

Gas chromatography is an importantbranch of chromatographic analysis, which mainly uses nitrogen, helium, etc. asmobile phases for chromatographic analysis. In specific pharmaceutical andchemical analysis, gas chromatography is usually used corresponding to liquidanalysis, and is often used in the separation and analysis of organic chemistrycompounds. Compared with other analytical methods, gas chromatography hasstronger flexibility, strong gas penetration, small particles and lowviscosity, so the use of gas chromatography in pharmaceutical industry isbecoming more and more extensive. In the application of gas chromatography forpharmaceutical and chemical analysis, the key is to use corresponding means tomake the chromatographic column well used, so that the use of gaschromatography in pharmaceutical industry can be effectively exerted.

Determination method of pesticideresidues in Chinese herbal medicine

Gas chromatography

Gas chromatograph not only has highsensitivity, good stability, but also has separation function, so it has beenwidely used in pharmaceutical and chemical analysis and detection. For example,the application of gas chromatography in the detection of pesticide residues inChinese herbal medicines can accurately obtain important information such aspesticide residues and residual components, which is of great significance tothe development of the Chinese herbal medicine industry. Due to the widevariety of Chinese herbal medicines, the chemical structures of different typesof Chinese herbal medicines also have significant differences. Therefore, whentesting Chinese herbal medicines, it is necessary to select the correspondingdetection methods according to the types and chemical structure characteristicsof Chinese herbal medicines to ensure the accuracy of the detection results.Under normal circumstances, the pesticide residues in Chinese herbal medicinesare not very high, so it is difficult for general detection instruments todetect the amount of pesticide residues. In the detection, other chromatographywith higher precision and higher sensitivity should be used for the detection.

Gas chromatography-massspectrometry

At present, the advanced nature ofthe gas chromatography - mass spectrometry, effectiveness has receivedgenerally agree that this will be the advantages and the organic combination ofgas chromatography mass spectrometry detection method, not only the detectionspeed, and the test results of high precision, suitable for a variety ofChinese herbal medicine detection work, so the use of gas chromatography inpharmaceutical industry is relatively wide. The application of gaschromatography-mass spectrometry for the detection of pesticide residues inChinese herbal medicine can be used to detect multiple pesticide residues atthe same time, with high sensitivity and relatively good detection effect andquality.

High performance liquidchromatography

In the detection process ofpesticide residues in Chinese herbal medicines, gas chromatography anddetectors are used to carry out monitoring work, but it cannot be applied tothe detection of non-volatile and strongly dependent pesticides. In this case,high-performance liquid chromatography was produced. High performance liquidchromatography is mainly used for the detection of pesticide residues in theform of liquid flow. In recent years, the sensitivity of the detector has beensignificantly improved, and the detection efficiency of Chinese herbal medicinepesticides has been significantly improved. It has a high level of automationand has limited application in Chinese herbal medicine pesticide residues.Compared with conventional gas chromatography, high performance liquidchromatography has good separation efficiency, high detection speed, and has awide range of applications. It is the main method for the detection ofpesticide residues in Chinese herbal medicine at this stage.

In summary, gas chromatography hasthe advantages of high analysis efficiency and good separation effect. Therational use of gas chromatography in pharmaceutical industry will help improvethe quality of analysis and promote the healthy and stable development of thepharmaceutical and chemical industry. However, it is worth noting that thereare also some defects in gas chromatography, and the research and optimizationof this technology should be continuously strengthened to improve the accuracyand scientificity of the results of pharmaceutical and chemical analysis.