Hantavirus pulmonary syndrome develops rapidly, with prodromal symptoms such as chills, fever, myalgia, headache, fatigue, etc., and gastrointestinal symptoms such as nausea, vomiting, diarrhea, etc. The fever is generally 38-40℃. The above symptoms last for as short as 12 hours and as long as several days. Most of them will quickly develop cough, shortness of breath and respiratory distress after 2-3 days, and non-cardiogenic pulmonary edema. Some patients may have renal damage. Prodromal stage, cardiopulmonary stage and recovery stage. Since the outbreak of Hantavirus pulmonary syndrome (HPS) with acute respiratory failure as the main manifestation in the Four Corners region at the junction of New Mexico, Colorado, Utah and Arizona in the southwestern United States in May 1993, cases have been found in 30 states in the United States. In addition to the United States, Canada, Brazil, Paraguay, Argentina, Chile, Bolivia in the Americas and Germany, the former Yugoslavia, Sweden, Belgium and other countries in Europe have reported cases of HPS. With the increase in HPS cases, various countries have conducted some research on this disease with a very high mortality rate. It was found that in 1959, a patient with clinical manifestations consistent with Hantavirus Pulmonary Syndrome was found to have anti-SNV IgG antibodies during follow-up in 1994 after treatment. Zaki et al. performed immunohistochemical examinations on autopsy tissues of 82 patients who died of non-cardiogenic pulmonary edema before 1993 and found that 21 cases had Hantavirus antigens, proving that they were Hantavirus Pulmonary Syndrome. The earliest case was in 1978, and Hantavirus antigens were widely deposited in endothelial cells, which was the same as the recent HPS. In view of the fact that heart failure can occur in addition to pulmonary edema, North America and other countries also call this disease Hantavirus cardiopulmonary syndrome (HCPS). my country is a high-incidence area of Hantavirus infection, and it is worth being vigilant whether this disease exists. Here is a brief description of the research situation abroad in recent years.