Herpangina is an acute, infectious, febrile disease caused by many group A coxsackieviruses and occasionally other enteroviruses, characterized by herpetic ulcerative mucosal lesions. The disease has an epidemic tendency and is common in infants and young children. The clinical features are sudden high fever accompanied by sore throat, headache, anorexia, and often pain in the neck, abdomen, and limbs. Vomiting and convulsions often occur in infants. Within 2 days of onset, a small number (rarely more than 12) of small (1-2 mm in diameter) gray-white herpes appear on the oral mucosa, surrounded by a red halo, mostly on the anterior part of the tonsils, but can also be located on the soft palate, tonsils, uvula, tongue, etc. Within the next 24 hours, the blisters rupture and become shallow ulcers, generally less than 5 mm in diameter, which heal within 1-5 days. Complications are rare. Symptoms generally disappear within 7 days. After infection, lasting immunity can be produced, but other viruses in group A or other enteroviruses may also cause recurrence.