This product belongs to the aminoglycoside antibiotics, which has antibacterial effects on Gram-negative bacteria such as Escherichia coli, aerogenes, Klebsiella, Proteus mirabilis, some indole-positive Proteus, Pseudomonas aeruginosa, some Neisseria, some non-pigmented Serratia and Shigella; the antibacterial effect on Pseudomonas aeruginosa is 3 to 5 times stronger than gentamicin. Among Gram-positive bacteria, Staphylococcus aureus (including β-lactamase-producing strains) is sensitive to this product; Streptococci (including Streptococcus pyogenes, Pneumococcus, Streptococcus faecalis, etc.) are resistant to this product. Anaerobic bacteria (Bacteroides), Mycobacterium tuberculosis, Rickettsia, viruses and fungi are also resistant to this product. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins.

This product is a specific H1 receptor blocker. At an effective antihistamine dose, this product and its metabolites are not easy to pass through the blood-brain barrier, so they rarely have central nervous system inhibitory effects.

Reproductive toxicity: When rats were given a dose of 38 times the human dose, their fertility was not significantly affected; when rats, mice and rabbits were given a dose of 50 times the human dose, no teratogenic effect on the fetuses was observed. Carcinogenicity: Rats and mice were orally given 1g/kg sucralfate (12 times the human dose) for 24 consecutive months, and the results showed no carcinogenicity.

It can promote blood circulation, reduce inflammation and relieve itching. It can be used for reducing inflammation, relieving itching, relieving pain and reducing edema.

This product (beclomethasone dipropionate) is a potent topical glucocorticoid that can reduce and prevent tissue responses to inflammation, thereby reducing the manifestations of inflammation. Borneol has analgesic and detumescent effects; menthol, when applied topically, has the effects of promoting blood circulation, anti-inflammatory and antipruritic, and can be used for anti-inflammatory, antipruritic, analgesic, and edema reduction; methyl salicylate has a local irritant effect, can promote local blood circulation, and also has an antipruritic effect.

It has a local stimulating effect, can promote local blood circulation, and also has an antipruritic effect

Has analgesic and swelling-reducing effects

This product (beclomethasone dipropionate) is a potent topical glucocorticoid that can reduce and prevent tissue responses to inflammation, thereby reducing the manifestations of inflammation. Borneol has analgesic and detumescent effects; menthol, when applied topically, has the effects of promoting blood circulation, anti-inflammatory and antipruritic, and can be used for anti-inflammatory, antipruritic, analgesic, and edema reduction; methyl salicylate has a local irritant effect, can promote local blood circulation, and also has an antipruritic effect.

It is a potent topical glucocorticoid that reduces and prevents tissue responses to inflammation, thereby alleviating the manifestations of inflammation.

This product can kill the tissue-stage strains of Plasmodium vivax, Plasmodium malariae, Plasmodium falciparum and Plasmodium ovale, especially Plasmodium vivax. It can also kill the gametocytes of various Plasmodium parasites, and has a particularly strong effect on Plasmodium falciparum, preventing it from developing in the mosquito body to block transmission. This product has a very weak effect on the erythrocytic stage. The antimalarial mechanism of primaquine is not fully understood, and it may be related to interference with DNA synthesis. Plasmodium erythrocytic stage parasites and tissue cells were cultured in primaquine solution for 8 hours. Electron microscopic observation showed that primaquine can change the mitochondrial morphology of Plasmodium parasites, manifested as mitochondrial swelling and the appearance of cytoplasmic vacuoles. This drug can inhibit the oxidation of mitochondria and significantly reduce the oxygen uptake of Plasmodium parasites. Primaquine is metabolized in the body and converted into quinoline quinone derivatives with strong oxidative properties, which can convert reduced glutathione (GSH) in erythrocytes into oxidized glutathione (GSSH). When the latter is reduced, it needs to consume reduced coenzyme II (NADPH). Since the infrared stage of malarial parasites consumes coenzyme II (NADP) during their development in the hepatic parenchymal cells, primaquine interferes with the reduction process of coenzyme II, causing a decrease in coenzyme II and seriously disrupting the sugar metabolism and oxidation process of malarial parasites.