Huarun Shuanghe Limin Pharmaceutical (Ji'nan) Co., Ltd.

It competitively blocks the binding of histamine to H2 receptors and inhibits the action of gastric acid. Its molar potency is 5 to 12 times that of cimetidine, making it a potent H2 receptor blocker.

This product belongs to the lincomycin antibiotics, which is a derivative of lincomycin. Its antibacterial spectrum is the same as that of lincomycin, and its antibacterial activity is 4 to 8 times stronger than that of lincomycin. It has high antibacterial activity against Gram-positive bacteria such as Staphylococcus (including penicillin-resistant strains), Streptococcus, Corynebacterium diphtheriae, Bacillus anthracis, etc. It also has good antibacterial activity against Gram-negative anaerobic bacteria. Most of the Bacteroides, including Bacteroides fragilis, Fusobacterium, Peptococcus, Peptostreptococcus, and Clostridium perfringens, are highly sensitive to this product. Gram-negative aerobic bacteria, including Haemophilus influenzae, Neisseria, and Mycoplasma, are resistant to this product. There is no cross-resistance between this product and penicillin, chloramphenicol, cephalosporins, and tetracyclines, but it has partial cross-resistance with macrolides and complete cross-resistance with lincomycin. The mechanism of action of this product is to bind to the 50S subunit of the bacterial ribosome, prevent the elongation of the peptide chain, and thus inhibit the protein synthesis of bacterial cells. This product is an antibacterial drug, but at high concentrations, it also has a bactericidal effect on certain bacteria.

Caloric supplementation, treatment of hypoglycemia, used with insulin to treat hyperkalemia, rapid intravenous push of hypertonic glucose injection to dehydrate tissues, maintain and regulate the osmotic pressure of peritoneal dialysis fluid

It achieves its antibacterial effect by inhibiting the activity of bacterial DNA gyrase (bacterial topoisomerase II), hindering bacterial replication; it has good antibacterial effect on most Enterobacteriaceae, Gram-negative bacteria, some Gram-positive bacteria, Legionella, Mycoplasma, Chlamydia, etc., but has poor effect on anaerobic bacteria and enterococci.

No specific pharmacological action is mentioned