It has a direct relaxant effect on the smooth muscles of the respiratory tract; it achieves bronchial dilation in part by releasing endogenous adrenaline and norepinephrine; it acts as a purine receptor blocker to counteract the contractile effect of adenine and other substances on the respiratory tract; it enhances the contractility of the diaphragm and improves respiratory function.

Phenothiazine antipsychotics block dopamine receptors (DA2) in the mesolimbic system and mesocortical pathways, and have blocking effects on dopamine (DA1) receptors, 5-hydroxytryptamine receptors, M-type acetylcholine receptors, and α-adrenaline receptors. At low doses, they can inhibit dopamine receptors in the medulla oblongata emetic chemoreceptor area, and at high doses, they can directly inhibit the vomiting center, producing a powerful antiemetic effect. They inhibit the body temperature regulation center, lower body temperature, block peripheral α-adrenaline receptors, dilate blood vessels, cause a drop in blood pressure, and have a certain effect on the endocrine system.

This product is a sulfonamide antibiotic. When used in combination with trimethoprim, it can double-block the bacterial folic acid metabolism and has good antibacterial effects on a variety of bacteria, especially on Escherichia coli, Haemophilus influenzae, and Staphylococcus aureus. The antibacterial effect is significantly enhanced compared to a single drug.

This product is a sulfonamide antibiotic. When used in combination with sulfamethoxazole, it can double-block the bacterial folate metabolism. The synergistic antibacterial effect is stronger than that of a single drug, and the number of drug-resistant strains is reduced.

1. Pharmacology This product is a sulfonamide antibacterial drug, a compound preparation of sulfamethoxazole (SMZ) and trimethoprim (TMP). It has good antibacterial effects on non-enzyme-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Proteus, Morganella, Shigella and other Enterobacteriaceae, Neisseria gonorrhoeae, Neisseria meningitidis, and Haemophilus influenzae. In particular, the antibacterial effect on Escherichia coli, Haemophilus influenzae, and Staphylococcus aureus is significantly enhanced compared with SMZ alone. In addition, it also has good antimicrobial activity against Chlamydia trachomatis, Nocardia asteroides, protozoa, and Toxoplasma in vitro. The mechanism of action of this product is: SMZ acts on the action of dihydrofolate reductase, and the combination of the two can double-block the folic acid metabolism of bacteria. The synergistic antibacterial effect of this product is enhanced compared with a single drug, and the number of drug-resistant strains is reduced. However, in recent years, bacterial resistance to this drug has also been on the rise.

This product is an analogue of diphenhydramine, which mainly suppresses cough center and relieves cough. It also has a weak antihistamine effect and has no dependence or tolerance. It takes effect 20-30 minutes after taking it and the effect lasts for 3-4 hours.

The main pharmacological action is to relax vascular smooth muscle. Nitroglycerin releases nitric oxide (NO), which is the same as endothelial relaxing factor, activating guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) in smooth muscle and other tissues, leading to dephosphorylation of myosin light chain, regulating the contractile state of smooth muscle, and causing vasodilation.