Henan Zhongjie Pharmaceutical Co., Ltd.

Moderate-acting diuretics can reduce water and sodium retention, thereby lowering blood volume and circulating blood volume, thereby playing a role in lowering blood pressure.

It has sedative, antianxiety and muscle relaxant effects.

It can improve the side effects of the above-mentioned drugs, such as multiple neuritis, palpitations, chest tightness, decreased appetite, etc.

It can increase capillary permeability, which is not only beneficial to the antihypertensive effect of diuretics, but also can counteract the adverse effects of rutin on diuresis and blood pressure reduction by reducing capillary permeability.

1. Pharmacological action: Reserpine and hydralazine hydrochloride in this product are basic antihypertensive drugs. Reserpine is an anti-noradrenergic antihypertensive drug that can deplete norepinephrine in peripheral sympathetic nerve endings, deplete catecholamines and 5-hydroxytryptamine storage in the heart, brain and other tissues to achieve antihypertensive, slow heart rate and inhibit the central nervous system. Reserpine can relieve anxiety, tension and headache in hypertensive patients. Hydrochlorothiazide and cyclopenthiazide are medium-acting diuretics that can reduce water and sodium retention, reduce blood volume, and reduce circulating blood volume, thus playing a hypotensive role. Promethazine hydrochloride has sedative, anti-anxiety and muscle relaxant effects. Vitamin B1 can improve the side effects of the above drugs, such as multiple neuritis, palpitations, chest tightness, and decreased appetite. Vitamin B6 can prevent neuritis, insomnia, restlessness, etc. that may be caused by hydralazine hydrochloride, and can also prevent the occurrence of side effects such as nausea and vomiting. Rutin can maintain vascular elasticity, enhance capillary resistance, promote cell proliferation and prevent blood cell aggregation, reduce vascular fragility, and reduce capillary permeability. Chloroquine phosphate can increase capillary permeability, which is not only beneficial to the antihypertensive effect of diuretics, but also can counteract the adverse effects of rutin on diuresis and blood pressure. 2. Toxicological studies: Animal experiments have teratogenic effects at 125 to 250 times the maximum clinical dose, and the commonly used clinical dose is 100 to 300 times, and the incidence of tumors increases.

Anti-noradrenergic antihypertensive drugs can deplete norepinephrine in peripheral sympathetic nerve endings, deplete catecholamines and 5-hydroxytryptamine storage in the heart, brain and other tissues to achieve the effects of anti-hypertension, slowing heart rate and inhibiting the central nervous system. It can relieve anxiety, tension and headaches in hypertensive patients.

Basic antihypertensive drugs.

It can prevent neuritis, insomnia, restlessness, etc. that may be caused by hydralazine hydrochloride, and can also prevent the occurrence of side effects such as nausea and vomiting.

Maintain vascular elasticity, enhance capillary resistance, promote cell proliferation and prevent blood cell aggregation, reduce vascular fragility, and reduce capillary permeability.

Anti-inflammatory effect: Contains glycyrrhizin and glycyrrhetinic acid, which can inhibit capillary hyperpermeability, resist histamine or reduce the responsiveness of cells to stimulation. It has an inhibitory effect on carrageenan-induced plantar edema in rats, cotton ball granuloma in rats, formaldehyde edema, and subcutaneous granuloma inflammation.

Expectorant effect: The platycodon saponins contained in it can increase the secretion of mucus in the respiratory tract, promote the discharge of bronchial mucosal fluid, and at the same time reflexively cause the secretion of bronchial mucus glands to increase, making the sputum dilute and easier to cough up.

Expectorant effect (indirect): It may stimulate the nerve endings of the gastric mucosa, reflexively causing an increase in the secretion of bronchial mucous glands, making the sputum dilute and easier to cough up.

1. Expectorant effect: The platycodon saponins contained in this product can increase the secretion of respiratory mucus and promote the discharge of bronchial mucosal fluid. At the same time, this product can stimulate the nerve endings of the gastric mucosa, reflexively causing an increase in the secretion of bronchial mucous glands, making the sputum dilute and easier to cough up. 2. Antitussive effect: After oral administration, this product can cover the inflamed pharyngeal mucosa, reduce its stimulation, and relax the bronchial smooth muscle, playing an antitussive effect. 3. Anti-inflammatory effect: This product contains glycyrrhizin and glycyrrhetinic acid, which can inhibit capillary hyperpermeability, resist histamine or reduce the responsiveness of cells to stimulation. This product has an inhibitory effect on carrageenan-induced plantar edema in rats, cotton ball granuloma in rats, formaldehyde edema, and subcutaneous granuloma inflammation.