Minocycline is a semi-synthetic tetracycline antibiotic with antibacterial activity against both Gram-positive and Gram-negative bacteria. Its antibacterial spectrum is basically the same as that of tetracyclines, and it exerts its antimicrobial effect by inhibiting protein synthesis. This product is relatively sensitive to sensitive Gram-positive bacteria (including Staphylococcus aureus, Streptococcus, meningococcus, etc.) and Gram-negative bacteria (such as gonococci, Haemophilus influenzae, etc.); it has a weaker effect on Gram-negative bacilli; it also has a certain effect on microorganisms such as Chlamydia trachomatis and Ureaplasma.

This product is a mucolytic agent that can increase the secretion of serous glands in the respiratory mucosa and reduce the secretion of mucous glands, thereby reducing sputum viscosity; it can also promote the secretion of pulmonary surfactant, increase bronchial ciliary movement, and make sputum easier to cough up.

No specific pharmacological effects mentioned

This compound preparation has the effect of lowering blood pressure.

It has a diuretic effect, increasing the excretion of urinary sodium, potassium, chloride, phosphorus and magnesium ions, while reducing the excretion of urinary calcium. Its mechanism of action is mainly to inhibit the reabsorption of sodium chloride in the anterior segment of the distal tubule and the proximal tubule (to a lesser extent), thereby increasing the Na⁺-K⁺ exchange in the distal tubule and collecting duct, and increasing K⁺ secretion. It may also increase the excretion of Na⁺ in the gastrointestinal tract through extrarenal mechanisms and lower blood pressure.

It can stimulate the α2 adrenergic receptors on the postsynaptic membrane of the medulla oblongata, excite inhibitory neurons, reduce the outflow of central sympathetic nerve impulses, and thus inhibit peripheral sympathetic nerve activity. It can also stimulate the α2 receptors on the presynaptic membrane of peripheral sympathetic nerves, enhance their negative feedback, reduce the release of norepinephrine from peripheral nerves, reduce peripheral vascular and renal vascular resistance, slow down heart rate, and lower blood pressure.

This compound preparation has the effect of lowering blood pressure.