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After being absorbed by the digestive tract, it is converted into active metabolites in the body. Its active metabolites exert analgesic, anti-inflammatory and antipyretic effects by inhibiting the synthesis of prostaglandins.

Glipizide is a second-generation sulfonylurea oral hypoglycemic drug. It mainly promotes the secretion of insulin by pancreatic β cells, especially the secretion of insulin stimulated by glucose; it also enhances the action of insulin, thereby effectively reducing blood glucose concentration and glycosylated hemoglobin; it can also improve hyperlipidemia, reduce triglyceride and cholesterol levels, and increase the ratio of high-density lipoprotein cholesterol in total cholesterol; it can also inhibit platelet aggregation and promote fibrinolysis, so it may have a certain preventive and therapeutic effect on vascular lesions. ① It promotes the secretion of insulin by pancreatic β cells, the prerequisite is that the pancreatic β cells still have a certain function of synthesizing and secreting insulin; ② By increasing the level of portal vein insulin or directly acting on the liver, it inhibits liver glycogenolysis and gluconeogenesis, and reduces the production and output of glucose by the liver.

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