Suicheng Pharmaceutical Co., Ltd.

This product is an H2 receptor antagonist, which can significantly inhibit the basal and nocturnal gastric acid secretion of normal people and ulcer patients, as well as the gastric acid secretion caused by pentagastrin, histamine and meals. Its potency in inhibiting gastric acid secretion is 5 to 12 times that of cimetidine in terms of mole. Intravenous injection of this product can reduce gastric acid secretion by 90%; it has a certain inhibitory effect on the secretion of pepsinogen. It has a protective effect on experimental gastric mucosal damage and acute ulcers. It has no effect on the secretion of gastrin and sex hormones.

1. Effect on water and electrolyte excretion: It can increase the excretion of water, sodium, chloride, potassium, calcium, magnesium, phosphorus, etc. It can inhibit the active reabsorption of NaCl by the thick wall segment of the renal tubular loop of Henle, reduce the osmotic pressure gradient difference of the medullary interstitial fluid, and lead to increased excretion of water, Na+, and Cl-; promote the secretion of K+ and H+ by the distal tubules, increase the excretion of K+ and H+; inhibit the reabsorption of Ca2+ and Mg2+ by the loop of Henle and increase their excretion. Short-term medication can increase uric acid excretion, and long-term medication can cause hyperuricemia. 2. Effect on hemodynamics: It inhibits the activity of prostaglandin degrading enzymes, increases the content of prostaglandin E2, dilates blood vessels, reduces renal vascular resistance, and increases renal blood flow; it dilates the pulmonary capacitance veins, reduces the permeability of pulmonary capillaries, reduces the amount of blood returning to the heart, and reduces the left ventricular end-diastolic pressure, which is helpful for the treatment of acute left heart failure.

It has a strong antipyretic effect on rabbits with fever caused by bacterial endotoxins; it can counteract the increased permeability of capillary walls caused by xylene or histamine, and has a significant antagonistic effect on adrenaline-induced acute pulmonary edema; it can shorten the sleep latency period of mice caused by sodium pentobarbital, prolong their sleep time, and enhance the subthreshold effect of sodium pentobarbital, causing mice to sleep, indicating a significant sedative effect; it can significantly promote the adrenal cortex function of rats and increase the body's emergency response to pathogen infection; it has an inactivating effect on influenza virus type AⅠ, type AⅢ, pneumonia adenovirus (Adv) type III, type IV, enterosyncytial virus and respiratory syncytial virus (RSV).

This product is an amide local anesthetic, which has a biphasic effect of excitation and inhibition on the central nervous system. At low doses, it causes analgesia and drowsiness, and increases the pain threshold; when the dose is increased, the effect or toxicity is enhanced, and it has an anticonvulsant effect at sub-toxic blood concentrations; excessive blood concentrations can cause convulsions. At low doses, it promotes the outflow of K+ in myocardial cells, reduces myocardial autonomy, and has an anti-ventricular arrhythmia effect; at therapeutic doses, it has no significant effect on myocardial electrical activity, atrioventricular conduction, and myocardial contraction; at high blood concentrations, it can slow down the heart conduction velocity, cause atrioventricular conduction block, inhibit myocardial contractility, and reduce cardiac output.