Magnesium Sulfate Injection

Magnesium ions can inhibit the activity of the central nervous system, inhibit the release of acetylcholine at the motor nerve-muscle junction, block conduction at the neuromuscular junction, reduce or relieve muscle contraction, and at the same time have a dilating effect on vascular smooth muscle, dilate spasmodic peripheral blood vessels, and lower blood pressure. Therefore, it has a preventive and therapeutic effect on eclampsia. It also has an inhibitory effect on uterine smooth muscle contraction and can be used to treat premature delivery.

Magnesium sulfate

This product is a colorless transparent liquid.

It can be used as an anticonvulsant. It is often used for hypertension during pregnancy. It lowers blood pressure, treats pre-eclampsia and eclampsia, and is also used to treat premature labor.

1. The initial dose for the treatment of moderate to severe pregnancy-induced hypertension, preeclampsia and eclampsia is 2.5-4 g. After diluting with 20 ml of 25% glucose injection, slowly inject it intravenously within 5 minutes, and then maintain it with 1-2 g intravenous drip every hour. The total amount for 24 hours is 30 g, which is monitored based on knee tendon reflex, respiratory rate and urine volume. 2. The dosage and method for the treatment of premature birth are similar to those for the treatment of pregnancy-induced hypertension. The initial loading dose is 4 g; after diluting with 20 ml of 25% glucose injection, slowly inject it intravenously within 5 minutes, and then use 60 ml of 25% magnesium sulfate injection, add it to 1000 ml of 5% glucose injection and drip it intravenously at a rate of 2 g per hour until 2 hours after uterine contractions stop. Then take oral β-adrenergic receptor agonists to maintain

1 Intravenous injection of magnesium sulfate often causes symptoms such as flushing, sweating, and dry mouth. Rapid intravenous injection can cause nausea, vomiting, palpitations, dizziness, and nystagmus in some cases. Symptoms can disappear by slowing down the injection speed. 2 In patients with renal insufficiency and large dosages, blood magnesium accumulation can occur. When the blood magnesium concentration reaches 5mmol/L, muscle excitability may be inhibited, sensory reactions may be sluggish, knee tendon reflexes may disappear, and breathing may begin to be inhibited. When the blood magnesium concentration reaches 6mmol/L, respiratory arrest, arrhythmias, and heart block may occur. Further increases in concentrations can cause cardiac arrest. 3 Continuous use of magnesium sulfate can cause constipation. Some patients may develop paralytic ileus, which improves after drug discontinuation. 4nbs

Drugs that are contraindicated with magnesium sulfate include polymyxin B sulfate, streptomycin sulfate, calcium gluconate, dobutamine hydrochloride, procaine hydrochloride, tetracycline, penicillin, and nafcillin (ethoxynaphthalene penicillin).

Store in a closed, cool place.

10ml:1g

Harbin Pharm. Group Sanjing Pharmaceutical Co., Ltd.

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