Granisetron Hydrochloride Injection

It is a highly selective 5-HT3 receptor antagonist, which has a good preventive and therapeutic effect on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Factors such as radiotherapy, chemotherapy and surgery can cause enterochromaffin cells to release 5-HT, which can activate the 5-HT3 receptors of the central nervous system or vagus nerve and cause vomiting reflex. The mechanism of this product to control nausea and vomiting is to antagonize the 5-HT3 receptors in the central chemoreceptor area and peripheral vagus nerve endings, thereby inhibiting the occurrence of nausea and vomiting. This product has high selectivity and no adverse reactions such as extrapyramidal reactions and excessive sedation.

The main ingredient of this product is granisetron hydrochloride, and its chemical name is 1-methyl-N-(endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide hydrochloride.

Colorless or almost colorless clear liquid.

This product is used to prevent or treat nausea and vomiting caused by chemotherapy, and to prevent and treat postoperative nausea and vomiting

Intravenous injection: Adults: The dosage is usually 3 mg, diluted with 20-50 ml of 5% glucose injection or 0.9% sodium chloride injection, and injected intravenously 30 minutes before treatment. The administration time should exceed 5 minutes. Most patients only need to be given once, and the prevention effect on nausea and vomiting can exceed 24 hours. If necessary, the number of administrations can be increased by 1-2 times, but the maximum daily dose should not exceed 9 mg. Patients with liver and kidney dysfunction do not need to adjust the dose.

Common adverse reactions include headache, fatigue, fever, constipation, and occasional transient asymptomatic increase in liver aminotransferase. These reactions are mild and do not require special treatment.

1. Patients who are allergic to this product or related compounds are prohibited from using this product. 2. Patients with gastrointestinal obstruction are prohibited from using this product.

Precautions for children: There is no experience of using this drug for children. Precautions for pregnancy and lactation: 1. Pregnant women should not use this drug unless necessary. 2. Lactating women should use this drug with caution. If this drug is used, breastfeeding should be stopped. Precautions for the elderly: No dosage adjustment is required for the elderly.

Not yet clear.

Keep away from light and store in a sealed container below 30℃.

According to C18H24N4O 1ml:1mg

36 months

Beijing Xiehe Pharmaceutical Co., Ltd.

• Founded in:

  1981-04-04

• Address:

  Building 7, No. 37 Yongwang Road, Daxing Biomedicine Industry Base, Zhongguancun Science Park, Daxing District, Beijing

• Tax NO.:

  91110115101618619W

• Registered Funds:

  60 million yuan

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