Phenytoin Sodium Tablets

Sodium and chloride are important components of extracellular fluid. An appropriate amount of sodium chloride can maintain normal blood and extracellular fluid volume and osmotic pressure. The sodium concentration in human serum remains constant, generally at 135-145 mmol/L. The loss of sodium chloride is often accompanied by water loss. Different loss ratios can cause hyperosmotic or hypoosmotic blood. Glucose is an important nutrient for the human body. Each 1g of glucose can produce 4 kcal of heat energy, so it is used to supplement calories. Glucose and sodium chloride injection can be used to supplement water, calories, electrolytes, and maintain the stability of body fluid volume and osmotic pressure.

This product is a sterile aqueous solution of glucose and sodium chloride.

This product is a colorless clear liquid.

Fluid replenishment medicine for children. Mainly used for maintaining fluid infusion for children with vomiting, diarrhea, dehydration caused by surgery, fever, pneumonia, etc.

Intravenous drip, dosage depends on the condition.

Generally, there are no adverse reactions. Improper use may cause: 1. Increased blood pressure, headache, and dizziness. 2. Weight gain and edema. 3. Increased blood volume leading to accelerated heart rate, chest tightness, shortness of breath, and lung wheezing.

Patients with the following diseases are prohibited from using this product: 1. Heart failure. 2. Pulmonary edema. 3. Brain edema, increased intracranial pressure. 4. Oliguria in acute renal failure; patients with chronic renal failure who do not respond well to diuretics. 5. Hypernatremia. 6. Diabetes. 7. Low plasma protein.

Precautions for children: Since the distribution volume and elimination half-life of children change with age, blood drug concentration should be measured frequently. The pharmacokinetics of this product are special for neonates or infants, and it is difficult to clinically assess the symptoms of poisoning, so it is generally not used first. Preschool children have strong liver metabolism, and blood drug concentration needs to be monitored multiple times to determine the frequency and dosage of medication. Precautions for pregnancy and lactation: This product can pass through the placenta and may cause teratogenesis, but it is believed that the risk of teratogenesis due to poor control of epileptic seizures is greater than the risk of medication, and the pros and cons should be weighed. Patients who can control seizures with this product should continue to take it during pregnancy and maintain effective blood concentration, and then readjust after delivery. Vitamin K should be supplemented one month before delivery, and vitamin K should be injected into the newborn immediately after delivery to reduce the risk of bleeding. This product can be secreted into breast milk, and mothers taking phenytoin are generally advised to avoid breastfeeding. Precautions for the elderly: The incidence of chronic hypoproteinemia in the elderly is high, and there are many combined medications for treatment. The interactions between drugs are complex. Caution should be exercised when using this product, the dosage should be low, and blood drug concentrations should be monitored frequently.

① Long-term use of acetaminophen in patients may increase the risk of liver poisoning and reduce the efficacy of this product; ② It is a liver enzyme inducer. When used in combination with corticosteroids, digitalis (including digoxin), oral contraceptives, cyclosporine, estrogen, levodopa, quinidine, oxytetracycline or tricyclic antidepressants, the effects of these drugs may be reduced; ③ Long-term drinking can reduce the concentration and efficacy of this product, but drinking a lot of alcohol while taking the medicine can increase the blood concentration; combined with chloramphenicol, isoniazid, phenylbutazone, and sulfonamides may reduce the metabolism of this product and increase the blood concentration, increasing the toxicity of this product; when used in combination with anticoagulants, the anticoagulant effect is initially increased, but it is reduced with continuous use; ④ When used in combination with drugs containing magnesium, aluminum or calcium carbonate, the bioavailability of this product may be reduced, and the two should be taken 2 to 3 hours apart; ⑤ When used in combination with hypoglycemic drugs or insulin, because this product can increase blood sugar, the dosage of the latter two needs to be adjusted; ⑥ In principle, patients using dopamine should not use this product; ⑦ When this product is used in combination with lidocaine or propranolol, it may enhance the inhibitory effect on the heart; ⑧ Although this product consumes folic acid in the body, increasing folic acid can reduce the concentration and effect of this product; ⑨ The effects of phenobarbital or primidone on this product vary greatly, and blood drug concentrations should be monitored frequently; when used in combination with valproic acid, there is a protein binding competition, and blood drug concentrations should be monitored frequently to adjust the dosage of this product. ⑩ When used in combination with carbamazepine, the latter has a lower blood concentration. If a large amount of antipsychotics or tricyclic antidepressants are used in combination, epileptic seizures may occur, and the dosage of this product needs to be adjusted.

Store in a sealed container. Valid for 24 months.

0.1 g

24 months

Hefei Limin Pharmaceutical Co., Ltd.

• Founded in:

  1998-10-22

• Address:

  No. 41, Yulan Avenue, Taohua Town, Feixi County, Hefei City, Anhui Province

• Tax NO.:

  91340123149193656T

• Registered Funds:

  50 million yuan

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