Pantoprazole Sodium for Injection

This product acts specifically on the gastric mucosal parietal cells, reducing the activity of H/KATPase in the parietal cells, thereby inhibiting the secretion of gastric acid. Compared with omeprazole and lansoprazole, this product has a weaker inhibitory effect on cytochrome P450-dependent enzymes. No adverse effects were found in either short-term or long-term administration of pantoprazole. This drug is non-carcinogenic, does not impair fertility, and does not induce teratogenesis. After continuous use of pantoprazole at a dose of 40 to 80 mg/d for 2.5 years, there was no change in various experimental parameters of liver enzymology and cholesterol metabolism.

Pantoprazole sodium.

This product is white or off-white loose lump or (and) powder.

It is suitable for acute upper gastrointestinal bleeding caused by duodenal ulcer, gastric ulcer, acute gastric mucosal lesions, complex ulcers, etc.

Intravenous drip. 1 bottle (40 mg) at a time, 1-2 times a day, each time dissolved in 100 ml of 0.9% sodium chloride injection, dripped within 1 hour. This product should not be prepared with liquids other than the above, and the pH value of the prepared solution should be no less than 9.

Occasionally, dizziness, insomnia, drowsiness, nausea, diarrhea, constipation, rash and muscle pain may occur, but the degree is relatively mild.

It is contraindicated for patients who are allergic to this product or have severe liver dysfunction.

Precautions for children: This experiment has not been conducted and there are no reliable references. Precautions for pregnancy and lactation: No studies have been conducted on pregnant women, but in animal reproduction studies, no effects on the fetus were seen, and the therapeutic benefits of using this drug in pregnant women may outweigh its potential harms. Alternatively, this drug has not been tested on animals, and there have been no sufficiently rigorous controlled studies on pregnant women. Precautions for the elderly: There is no significant change in the pharmacokinetics (clearance, half-life, bioavailability) of pantoprazole in elderly patients, so the elderly do not need to change the dose.

1. In vivo, higher doses of pantoprazole do not change the elimination rate of diazepam, and its serum concentration is not affected by diazepam, indicating that diazepam does not affect the metabolism of pantoprazole. 2. Pantoprazole has no interaction with aminophylline, warfarin, contraceptives, phenytoin sodium, nifedipine, aminopyrine, digoxin, diclofenac, metoprolol and antacids.

Keep in a dark, airtight container in a cool place (not exceeding 20℃).

40mg

24 months.

Double-Crane Pharmaceutical(Hainan) Co., Ltd.

• Founded in:

  2004-04-07

• Address:

  No. 2, Yaogu Sanheng Road, Yaogu Industrial Park, Haikou National High-tech Zone

• Tax NO.:

  91460100754396590D

• Registered Funds:

  150 million yuan

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