Oxytetracycline Hydrochloride Capsules

Tetracycline antibiotics. This product is a broad-spectrum antibacterial agent. Many Rickettsia, Mycoplasma, Chlamydia, and Spirochete are sensitive to this product. Enterococci are resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia, etc. are also sensitive to this product. Due to the widespread use of oxytetracycline and tetracyclines over the years, common clinical pathogens have serious resistance to oxytetracycline, including Gram-positive bacteria such as Staphylococcus and most Gram-negative bacteria. There is cross-resistance between this product and different varieties of tetracycline antibiotics. The mechanism of action of this product is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, inhibit the growth of the peptide chain and affect the synthesis of bacterial proteins.

Oxytetracycline.

This product is a capsule with yellow contents.

1. This product can be used as a drug of choice for the following diseases: (1) Rickettsial diseases, including epidemic typhus, endemic typhus, Rocky Mountain fever, scrub typhus and Q fever. (2) Mycoplasma infections. (3) Chlamydia infections, including psittacosis, venereal diseases, lymphoedema, nonspecific urethritis, salpingitis, cervicitis and trachoma. (4) Relapsing fever. (5) Brucellosis. (6) Cholera. (7) Tularemia. (8) Plague. (9) Chancroid. It should be used in combination with aminoglycosides for the treatment of brucellosis and plague. 2. Due to the serious drug resistance of common pathogens to this product, it can be used as a drug of choice only when the pathogens are sensitive to this product: Escherichia coli, Enterobacter aerogenes, Acinetobacter rofi, Shigella, Haemophilus influenzae (limited to

Oral administration: 1.5-2g per day for adults, divided into 3-4 times; 30-40mg/kg per day for children over 8 years old, divided into 3-4 times. This product is contraindicated for children under 8 years old.

1. Digestive system: Gastrointestinal symptoms such as nausea, vomiting, upper abdominal discomfort, bloating, diarrhea, and occasional reports of pancreatitis, esophagitis, and esophageal ulcers, mostly occur in patients who are bedridden immediately after taking the drug. 2. Hepatotoxicity: Usually fatty liver degeneration. Pregnant women and patients with pre-existing renal impairment are prone to hepatotoxicity, but hepatotoxicity can also occur in patients without the above conditions. 3. Allergic reactions: Mostly maculopapular rashes and erythema. In addition, urticaria, angioedema, allergic purpura, pericarditis, and exacerbation of systemic lupus erythematosus can be seen. Exfoliative dermatitis is not common. Occasionally, anaphylactic shock and asthma occur. Some patients using tetracycline have photosensitivity when exposed to the sun. Therefore, patients should be advised not to expose themselves directly to sunlight or ultraviolet rays, and to stop taking the drug immediately if erythema appears on the skin. 4. Blood

Patients with a history of allergy to tetracyclines are contraindicated.

Precautions for children: This product can form stable calcium compounds in any bone tissue, leading to yellowing of permanent teeth, poor enamel development and bone growth inhibition, so it is not suitable for children under 8 years old. Precautions for pregnancy and lactation: This product can enter the fetus through the placental barrier and deposit in the calcium area of teeth and bones, causing fetal tooth discoloration, poor enamel regeneration and inhibition of fetal bone growth. In addition, this type of drug has teratogenic effects in animal experiments, so pregnant women should not use this product. This product can be secreted from breast milk, and the concentration in breast milk is high. It has the potential to cause serious adverse reactions to infants. Lactating women should suspend breastfeeding when using it. Precautions for the elderly: Elderly patients are often accompanied by renal impairment. The use of this product is prone to hepatotoxicity. Therefore, when elderly patients use this product, the dosage should be adjusted according to the degree of renal impairment.

1. When used with antacids such as sodium bicarbonate, the absorption of this product will be reduced and its activity will be reduced due to the increase in the pH value in the stomach. Therefore, antacids should not be taken within 1 to 3 hours after taking this product. 2. Drugs containing metal ions such as calcium, magnesium, and iron can form insoluble complexes with this product, reducing its absorption. 3. When used with the general anesthetic methoxyflurane, its nephrotoxicity can be enhanced. 4. When used with strong diuretics such as furosemide, it can aggravate renal damage.

Seal and keep out of light in a cool place.

0.25g

24 months